STRESS RESPONSIVENESS IN ABNORMAL REPETITIVE BEHAVIOR

描述：目前的培训方案是一个更大项目的一部分 自发性精神分裂症的发生发展及神经生物学基础研究 鹿小鼠的刻板印象行为。这项工作代表了一个动物模型 刻板印象的运动障碍，因此将是对我们 重复性行为障碍与刻板印象的研究 有发育障碍的个人。压力一直被认为是 在异常的发病机制和表达中起重要作用 不同临床人群和动物的重复行为 在恶劣的环境环境中饲养或居住的。不幸的是，很少有人 有数据可以检验这一假设。因此，本项目 将直接测试应激在发病机制中的作用和表达 刻板的行为。解决这个问题的第一个方法是评估 应激反应增强对儿童精神分裂症发生的影响 鹿鼠的自发刻板印象。这涉及到增加压力 鹿小鼠通过延长母体分离和 评估刻板印象行为的发展。第二个目标是 评估刻板印象和非刻板印象的应激反应指数 鹿鼠。这一目标包括评估压力引起的HPA的改变。 轴和多巴胺在定型和非定型小鼠中的功能。在……里面 为了更全面地了解糖皮质激素和多巴胺的作用 糖皮质激素受体在定型糖皮质激素受体病理生理学中的作用 大鼠海马区基因表达和多巴胺转运体密度 多巴胺终端场也将在刻板印象和 非刻板印象的鹿鼠

DESCRIPTION: The current training proposal is part of a larger project investigating the development and neurobiological basis of spontaneous stereotyped behaviors in deer mice. This work represents an animal model of Stereotypic Movement Disorder and thus will be a close complement to our studies of stereotypy and related repetitive behavior disorders in individuals with developmental disabilities. Stress has been assumed to play an important role in the pathogenesis and expression of abnormal repetitive behaviors in various clinical populations as well as animals reared or housed in adverse environmental circumstances. Unfortunately, few data are available to test such an assumption. Thus, the present project will test directly the role of stress in the pathogenesis and expression of stereotyped behavior. The first approach to this problem will be to assess the effect of increased stress responsiveness on the development of spontaneous stereotypy in deer mice. This involves increasing the stress responsiveness of deer mice through extended maternal separation and assessing the development of stereotyped behavior. The second aim is to assess indices of stress responsiveness in stereotypic and non-stereotypic deer mice. This aim involves assessing stress-induced alterations in HPA axis and dopamine function in both stereotypic and non-stereotypic mice. In order to understand more fully the role that glucocorticoid and dopamine function play in the pathophysiology of stereotypy, glucocorticoid receptor mRNA expression in hippocampus and dopamine transporter densities in dopamine terminal fields will also be compared in stereotypic and non-stereotypic deer mice