STRUCTURE BASED VISUAL ACCESS TO BIOMEDICAL INFORMATION

描述（摘自应用摘要）： 本建议中所述的工作是开发在线组合空间和 用于表示、存储、检索和可视化的符号方法 解剖学信息，既作为理解人类生物学的手段， 结构，并作为一个视觉门户进入迅速增长的阵列， 生物医学中的在线文本信息源。 在本提案中，我们 将解决一些基本的问题，涉及到结合空间 和象征性的解剖信息，并将测试这些问题的解决方案， 在基于万维网的胸部三维解剖信息系统中， 内脏 临床医生，研究人员和学生将能够使用这个 系统检索特定的解剖知识，形式为 动态生成的交互式3D场景和相应的符号 信息，而无需查阅硬拷贝地图集或导航 通过不相关的计算机图像， 信息. 为了建立这个系统，我们需要解决 空间建模的基本问题，这些模型的组织， 基于知识的空间数据库系统，以及通过 联机用户界面和空间查询处理器。 具体目标为 这些建议是：1）建立一个知识库， 整合解剖学的空间和符号模型，2）实现解剖学 结合了基于知识的空间和符号的信息系统 检索与动态生成的三维场景，3）开发的方法， 实时平滑地渲染场景并与场景交互，以及4） 通过整合其他空间数据并将其提供给 解剖学医学生和放射治疗规划师。 成就 这些目标将导致一个有用的信息系统的解剖 可以用新技术增强的胸腔脏器， 性能图形和虚拟现实。 并且该信息 我们在这个项目中建立的框架和方法将是可推广的， 仅适用于身体不同部位的大体解剖学， 解剖数据库，而且结构信息的管理 与细胞和分子生物学有关，以及发育和 神经生物学

DESCRIPTION (Taken from application abstract): The long term goal of the work described in this proposal is to develop on-line combined spatial and symbolic methods for representing, storing, retrieving and visualizing anatomical information, both as a means for understanding human biological structure, and as a visual gateway into the rapidly increasing array of on-line text-based information sources in biomedicine. In this proposal we will address some of the fundamental problems involved in combining spatial and symbolic anatomic information, and will test solutions to these problems in a World Wide Web based 3-D anatomy information system for the thoracic viscera. Clinicians, researchers and students will be able to use this system to retrieve specific anatomic knowledge, in the form of dynamically-generated interactive 3-D scenes and corresponding symbolic information, without the need to consult hard copy atlases or to navigate through irrelevant computer-based images before finding the needed information. In order to build this system we will need to address fundamental problems in spatial modeling, organization of these models in a knowledge based spatial database system, and access to the models via an on-line user interface and spatial query processor. The specific aims for this proposal are: 1) develop a knowledge base that organizes and integrates spatial and symbolic models of anatomy, 2) implement an anatomy information system that combines knowledge-based spatial and symbolic retrieval with dynamically generated 3-D scenes, 3) develop methods for smoothly rendering and interacting with the scene in real-time, and 4) evaluate the system by integrating other spatial data and by providing it to anatomy medical students and radiation treatment planners. Accomplishment of these aims will lead to a useful information system for the anatomy of the thoracic viscera that can be enhanced with new technology such as high performance graphics and virtual reality. Moreover, the information framework and methods we establish in this project will be generalizable not only to gross anatomy in different regions of the body and to different anatomical databases, but also to the management of structural information pertaining to cellular and molecular biology, as well as developmental and neurobiology.