MICROELECTROMECHANICAL PRECISION DRUG DELIVERY

描述：（逐字来自申请人的摘要）根据我们对 神经生理学迅速扩展，它变得越来越重要， 开发一种系统，用于在中枢神经系统中精确定位药物输送， 系统我们打算使用全新的 微机电系统（MEMS）技术。我们的解决方案结合了 单通道微驱动器与微通道药物递送探针，以形成 可操纵微离子电渗给药系统。在第一阶段，我们将建立 并在海马脑切片制备中测试它。 具体来说，我们将评估1）和静电洗牌微电机 (ESM)2）带集成齿轮的静电摆动微电机 列车，并选择一个为微驱动器。我们还将设计一种药物输送系统 探针使用体硅加工和安装在微驱动器上。 如果这个原型在海马脑切片实验中成功， 我希望进入第二阶段，届时我们将：1）加强探测， 同时记录电活动，以及2）植入微探针， 大鼠模型中的微致动器以展示多位点精确药物递送 在清醒的动物身上。这是我们的长期目标，市场这些 用于研究和临床探索的自推进微探针 例如将药物靶向递送至癫痫发作病灶的应用， 帕金森患者的多巴胺输送。 拟议商业应用：不可用

DESCRIPTION: (Verbatim from the Applicant's Abstract) As our understanding of neurophysiology rapidly expands, it is becoming increasingly important to develop a system for precision localized drug delivery in the central nervous system. We intend to develop this solution using radical new microelectromechanical systems (MEMS) technology. Our solution combines a single channel microdrive with a microchannel drug delivery probe to form a steerable microiontophoresis drug delivery system. In Phase I, we will build the prototype device and test it in a hippocampal brain slice preparation. Specifically, we will evaluate both 1) and electrostatic shuffle micromotor (ESM) and 2) an electrostatic wobble micromotor (EWM) with integrated gear trains, and select one for the microdrive. We will also design a drug delivery probe using bulk silicon machining and mount it on the microdrive. If this prototype is successful in the hippocampal brain slice experiments, we hope to proceed to Phase II, when we will: 1) enhance the probes to simultaneously record electrical activity, and 2) implant the microprobes and microactuators in a rat model to demonstrate multi-site precise drug delivery in awake behaving animals. It is our long term goal to market these self-propelled microprobes for use in research, and to also explore clinical applications such as targeted drug delivery to epileptic seizure foci and dopamine delivery in Parkinson's patients. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE