COLON POLYP DIAGNOSIS BY VOLUME MICROPROBE SPECTROSCOPY

本研究项目的目标是光学活检的应用 结肠腺瘤性息肉的鉴别技术。 为此将开发特定的光学仪器和软件 任务。光谱检测异型增生已被证明，并是 109.91接受。它已被证明是敏感和选择性的，特别是在 被采样的组织体积仅限于粘膜层。为 为此，我们提出了一种类似于共焦显微镜的技术，它 我们用了大量的微探针显微镜。这种光学技术非常适合 用于通过典型结肠镜的工作通道进行手术。 该应用程序包括对人体受试者的临床试验。 拟议的商业应用：结直肠癌索赔约 美国每年有6万人。这是一种高度可治愈的疾病，如果 在其早期阶段被检测到。所提出的光学活检仪 将提高诊断能力，并可能修改当前的做法 切除无法区分的良性增生性小息肉 癌前息肉。因此，商业潜力很大， 特别是考虑到大约1550万结肠镜和 美国每年都会进行乙状结肠镜检查。即使是其中的10% 程序包括光学活组织检查、光学程序的数量 每年将超过160万。

The goal of this research program is the application of optical biopsy techniques to the identification of adenomatous polyps in the colon. Specific optical instrumentation and software will be developed for this task. Spectroscopic detection of dysplasia has been demonstrated, and is accepted. It has been shown to be sensitive and selective, especially if the tissue volume being sampled is confined to the mucosal layer. For this reason, we propose a technique similar to confocal microscopy, which we Volume MicroProbe microscopy. This optical technique is ideally suited for operation through the working channel of a typical colonoscope. Clinical trials with human subjects are included in the application. PROPOSED COMMERCIAL APPLICATION: Colorectal cancer claims approximately 60,000 individuals in the US annually. It is a highly curable disease if detected in its early stages. The proposed optical biopsy instrumentation will improve diagnostic capability and may modify current practice of removing small benign hyperplastic polyps which are indistinguishable from precancerous polyps. Therefore, the commercial potential is high, especially considering that approximately 15.5M colonoscopes and sigmoidoscopies are performed in the US each year. If even 10% of these procedures include an optical biopsy, the number of optical procedures will be over 1.6M annually.