CUTANEOUS MELANOMA IN ARIZONA--IDENTIFICATION OF KINDRED

亚利桑那州南部是世界上皮肤癌发病率最高的地区之一 亚利桑那州癌症中心有一个活跃而独特的登记处， 确定东南部三个地区内诊断出的所有皮肤癌 州的县。 然而，人们对基因的作用知之甚少。 在皮肤黑色素瘤的病因中， 区域以及遗传和环境，尤其是 紫外线照射，相互作用。 该项目的主要目标是 开发和评估一个系统，以常规识别家族史， 新诊断的黑色素瘤患者，并开发一个储存库， 黑色素瘤病例的遗传信息。 这 为发展以前所需的资源和经验而提出的项目 提出一个更复杂的遗传流行病学调查， 皮肤恶性黑色素瘤亚利桑那州。 这个为期两年的项目建议将收集家庭 所有皮肤恶性黑素瘤病例的历史数据， 亚利桑那州东南部皮肤癌登记处 这次例行评估 将允许从定义的地理种群中识别 潜在的黑色素瘤家族有一个以上的一级亲属， 黑素瘤 然后，这些病例和家庭可以用于 招募到随后的重点遗传研究中。 我们建议 还收集和分析用于突变分析的样品， p16 INK 4/CDK 2N基因在一系列选择性激酶中的表达。

Southern Arizona has among the highest skin cancer rates in the world and the Arizona Cancer Center has an active and unique registry for identification of all skin cancers diagnosed within three southeastern counties of the state. Little is known, however, about the role genetic risk factors have in the etiology of cutaneous melanoma within this region and how genetics and environment, most particularly high ultraviolet exposures, interact. The primary objective of this project is to develop and evaluate a system to routinely identify the family history of newly diagnosed melanoma patients and develop a repository of genetic information for melanoma cases in a defined population. This project proposed to develop the resources and experiences needed prior to proposing a more complex genetic epidemiologic investigation in Arizona of cutaneous malignant melanoma. This two year project proposes to incorporate the collection of family history data for all cutaneous malignant melanoma cases identified by the Southeastern Arizona Skin Cancer Registry. This routine assessment would allow identification from a defined geographic population of potential melanoma families with more than one first-degree relative with melanoma. These cases and families could then be available for recruitment into subsequent, focused genetic studies. We propose to also collect and analyze samples for mutational analyses of the p16INK4/CDK2N gene in a series of select kindreds.