SPECIFIC ROLE OF GENISTEIN IN ESTROGEN METABOLISM

描述：（申请人的描述）有越来越多的证据表明， 植物雌激素，也被称为植物雌激素，其来源于大豆， 除了具有抗增殖特性外， 雌激素的浓度、产生、代谢和排泄及其 对靶组织的影响。 连续性前瞻性研究， 改变生物标志物的异黄酮的特定成分的作用， 与乳腺癌的发生和发展有关的 available. 研究人员提出了一项对照，随机临床试验，其中66 年龄在25-55岁之间的绝经前、杂食性、无乳腺癌的女性， 随机分配到一个补充大豆（40毫克， 染料木黄酮/天）或对照组消耗安慰剂、等热量 补充酪蛋白，为期12周，并希望观察 人体测量、营养和激素生物标志物。 他们假设， 增加染料木黄酮的摄入量将导致血清性激素升高 结合球蛋白并减少游离雌二醇和雌酮。 在他们的飞行员 研究，他们能够证明他们的建议的可行性， 保持一组妇女补充大豆，而不改变摄入量， 其他营养素。 在以前的研究中，他们已经证明了他们的能力， 监测人体测量和性激素变量的变化， 在乳腺癌患者中。 如果增加大豆的摄入量， 富含植物雌激素的食物会改变性激素环境， 饮食中，补充富含植物雌激素的食物，如大豆摄入量， 饮食干预可降低乳腺癌风险。 另外基于 这项研究的结果，使用膳食补充剂的预防性治疗， 例如染料木黄酮，几乎没有副作用， 更有争议的治疗性激素补充方案， 目前用于降低乳腺癌风险。 另外研究 检查除了脂肪之外，补充染料木黄酮的效果， 可以检查身体成分、体重和性激素的减少 关于降低荷尔蒙癌症风险。 虽然在一个 根据现有文献中的证据， 预计这项拟议的研究将产生平行的结果， 降低前列腺癌风险的作用。

DESCRIPTION: (Applicant's Description) There is increasing evidence that phytoestrogens, also referred to as isoflavones, which are derived from soy, in addition to possessing antiproliferative properties, may alter the plasma concentration, production, metabolism and excretion of estrogens and their impact on target tissues. Definitive prospective studies testing the effects of specific components of isoflavones that alter biomarkers that are implicated in the initiation and promotion of breast cancer are not available. The investigators propose a controlled, randomized clinical trial where 66 pre menopausal, omnivorous, breast cancer free women between ages 25-55 are randomized to one experimental group supplemented with soy (40 mgs of genistein/day) or to a control group consuming a placebo, an isocaloric supplement of casein, for a 12 week period and wish to observe changes in anthropometric, nutritional and hormonal biomarkers. They hypothesize that increased intake of genistein will produce an elevation in serum sex-hormone binding globulin and decrease a free estradiol and estrone. In their pilot study, they were able to demonstrate the feasibility of their proposal to maintain a group of women on soy supplementation without altering intake of other nutrients. In previous studies, they have demonstrated their ability to monitor changes in anthropometric and sex-hormone variables in similar populations and in breast cancer patients. If increased intake of soy or foods rich in phytoestrogens alter the sex hormone milieu, manipulation of diet, supplemented with foods rich in phytoestrogens such as soy intake by dietary intervention may reduce breast cancer risk. In addition, based on the results of this study, prophylactic therapies using dietary supplements such as genistein, with practically no side effects, may be used to replace the more controversial therapeutic hormonal supplementation regimens that are currently used for breast cancer risk reduction. In addition, studies examining the effect of genistein supplementation, in addition to fat reduction on both body composition, weight and sex-hormones can be examined with respect to hormonal cancer risk reduction. Although conducted on a female population, based on evidence in the current literature, it is anticipated that this proposed study will generate results which parallel effects in prostate cancer risk reduction.