ANTIGENS OF BRONCHIAL EPITHELIAL TUMORS

描述：(改编自申请人的摘要)建议的 研究的目标是开发预防和治疗疫苗。 患上了肺癌。所描述的方法有助于隔离和 人支气管免疫原性抗原的特性研究 上皮性肿瘤细胞。重点放在共有的抗原上 由独立的支气管瘤引起。这样的分子可能是 广谱疫苗用于预防和治疗流行性感冒的基础 肺癌。这些研究的最初焦点是体外模型。 多种肿瘤是由致癌物或致癌基因衍生的 从相同的锚定依赖、接触抑制、 非致瘤性支气管上皮细胞系。此产品的可用性 一组相关的正常和肿瘤细胞系促进了设计 识别共有肿瘤抗原的良好对照实验。 建议的商业应用： 商业应用是开发针对肺癌的疫苗。

DESCRIPTION: (Adapted from the applicant's abstract) The proposed research is directed at developing vaccines for prevention and therapy of lung cancer. Methods described to facilitate isolation and characterization of antigens that are immunogenic in human bronchial epithelial tumor cells. Emphasis is placed on antigens that are shared by independently derived bronchial tumors. Such molecules may be the basis for broadly effective vaccines for the prevention and therapy of lung cancer. The initial focus of these studies is an in vitro model in which multiple tumors are derived by carcinogens or oncogene transformation from the same anchorage dependent, contact inhibited, non-tumorigenic bronchial epithelial cell line. Availability of this panel of related normal and tumor cell lines facilitates the design of well-controlled experiments to identify shared tumor antigens. PROPOSED COMMERCIAL APPLICATION: The commercial application is to develop vaccines against lung cancer.