PSEUDO-DXA BONE MINERAL DENSITY FROM 3DQCT EXAMS

描述：调查人员提议测试 开发骨矿转化算法和软件 从X射线计算机断层扫描到投影格式的测量数据 可与双能X射线吸收测量仪相媲美，而且 由他们的摘要描述的： QCT和DXA是临床上用来测量骨密度的方法。 在中央骨架上。DXA被认为是可供选择的方法 由内科医学界，但世界各地的中心数量 做DXA还不足以使这项技术普遍可用。 CT扫描仪的数量要多出一个数量级。 3DQCT通过消除重新定位误差来提高QCT的精度 在连环考试中。获取体积数据集并将其传输到 一台用于分析的PC。临床上，3DQCT用于脊柱骨矿物质 密度(BMD)分析，也在区域BMD的研究研究中 在股骨近端。CT分离骨骼中的分割算法 来自软组织或来自组织的造影剂填充的血管，以及 生成的数据被投影到2D图像中以进行可视化。我们会 将这些方法应用于3DQCT，构建骨密度的伪DXA图像 分析。关键因素是准确测量骨密度的能力。 在3DQCT数据集中逐个体素。 这项提议的长期目标是表明3DQCT可以 替代DXA，同时使用大量的 使用DXA开发的临床知识。如果成功，这项工作可以 让任何有CT扫描仪的网站都能获得类似DXA的骨密度结果。 建议的商业应用： 建议的商业应用程序不可用。

DESCRIPTION: The investigators propose to test the feasibility of developing algorithms and software for conversion of bone mineral measurement data from X-ray computed tomography to a projection format comparable to a dual-energy X-ray absorptiometry device, as further described by their abstract: "QCT and DXA are clinically used methods for measurement of bone density in the central skeleton. DXA is considered to be the method of choice by the internal medicine community, but the number of centers worldwide doing DXA is not sufficient to make this technique generally available. There is an order of magnitude larger number of CT scanners. "3DQCT improves the precision of QCT by eliminating repositioning errors in serial exams. A volumetric data set is acquired and transferred to a PC for analysis. Clinically, 3DQCT is used for spinal bone mineral density (BMD) analysis, but also in research studies for regional BMD in the proximal femur. Segmentation algorithms used in CT separate bone from soft tissue or contrast-filled vessels from tissue, and the resulting data are projected into a 2D image for visualization. We will apply these methods to 3DQCT to construct pseudo-DXA images for BMD analysis. The key factor is the ability to measure BMD accurately voxel-by-voxel in the 3DQCT data set. "The long-term objective of this proposal is to show that 3DQCT can substitute for DXA, while at the same time using the vast set of clinical knowledge developed using DXA. If successful, this work can make DXA-like BMD results available to any site with a CT scanner." PROPOSED COMMERCIAL APPLICATION: Proposed commercial application not available.