ANTICANCER AGENTS FROM UNIQUE NATURAL PRODUCTS SOURCES

该计划的基本主题是将发现 来自栖息生物的具有生物活性的新天然产物 独特的生态位和机制导向的癌症生物学。这个 总体目标是确定临床上有用的药物， 靶向人类实体肿瘤疾病和相关感染 免疫缺陷。私家侦探爱尔兰博士将负责 该计划的管理，包括财务管理， 协调各团体之间的沟通和传播 数据，跟踪优先线索并安排与NIH的会议 官员们。爱尔兰博士还将监督一个天然产品子项目 研究海洋无脊椎动物的化学和 伴生微生物。克莱默医生将对药物负责 这个项目的发展方面。这将包括初始测试 由氰胺的天然产品组提供的样品 肿瘤药物筛选(CODS)，作用机制研究，动物 动物模型的毒理学和体内抗肿瘤研究。克莱默博士 还将监督免疫刺激分析中的样本测试。Dr。 Maiese将负责一个海洋微环境研究的子项目 有机体。将特别强调微生物 从特定环境中获得。Maiese博士的团队将是 负责分离、分类鉴定和发酵 受试者的微生物。克拉迪博士将监督一项天然产品 新型内生真菌研究的子计划和较小的工作 用X射线衍射法对铅的表征。安徒生博士 将监督一个研究海洋的天然产品子项目 无脊椎动物和相关微生物。

The underlying theme of this program is to integrate discovery of novel biologically active natural products from organisms that inhabit unique ecological niches with mechanism-directed cancer biology. The overall goal is the identification of clinically useful drugs that target human solid tumor diseases and related infections caused by immune deficiency. The PI, Dr. Ireland will be responsible for administration of the program, including financial management, orchestrating communication between the groups and dissemination of data, tracking of priority leads and arranging meetings with NIH officials. Dr. Ireland will also oversee a natural products subprogram for studies of the chemistry of marine invertebrate animals and associated microorganisms. Dr. Kramer will be responsible for the drug development aspect of this program. This will include initial testing of samples supplied by the natural products groups in Cyanamid's Oncology Drug Screen (CODS), mechanism of action studies, animal toxicology and in vivo antitumor studies in animal models. Dr. Kramer will also oversee testing of samples in immune stimulation assays. Dr. Maiese will oversee a subprogram for studies of marine micro- organisms. Particular emphasis will be placed on micro-organisms obtained from specific environments. Dr. Maiese's group will be responsible for isolation, taxonomic identification and fermentation of subject micro-organisms. Dr. Clardy will oversee a natural products subprogram for studies of novel endophytic fungi and a smaller effort on the characterization of leads by X-ray diffraction. Dr. Andersen will oversee a natural products subprogram for studies of marine invertebrate animals and associated microorganisms.