PERMEABILITY CHARACTERISTICS OF DENTIN

描述（改编自研究者摘要）：牙本质粘结 通常包括使用酸性调理剂来去除玷污层 使牙本质表面脱矿，暴露出下面的胶原纤维 管间牙本质基质。 这种脱矿物质基质具有如此低的 弹性模量，如果允许空气干燥，它可以崩溃，一个常见的 临床程序。 当它塌陷时，胶原纤维之间的空间 被认为会逐渐变小，可能渗透性会降低， 然而，树脂在树脂过程中必须通过这些通道扩散 前将芯片 如果脱矿基质的弹性模量可以 增加到临界值以上时，网络可能不会崩溃， 干燥，从而保持对树脂单体的可渗透性。 各种 将评估程序对脱矿牙本质的修复能力， 矩阵 到目前为止，还没有人开发出定量的方法来衡量 树脂渗入脱矿牙本质。 的渗透性 将测量湿基质与干基质中脱矿牙本质与树脂的比率。 干燥塌陷的纤维网络被认为对树脂的渗透性较低 单体比湿，扩大网络。 拟议中的研究将测试， 假说. 研究了不同酸性调理剂对渗透性的影响， 胶原蛋白的拉伸性能、尺寸和溶解度将在 脱矿牙本质和肌腱作为不溶性胶原的例子 矩阵 酸性调理剂的几种不同的盐添加剂将 来评估哪一种能最好地保护胶原蛋白不变性。 脱矿牙本质基质随时间的稳定性知之甚少 在水中 脱矿牙本质基质的长期稳定性， 在没有树脂渗透的情况下，在水溶液和非水溶液中， 评价基质可能发生水解降解的问题， 拉伸性能随时间的损失。 这些宏观结果将是 在微观层面上使用SEM和原子力重新检查 一种改进的测量弹性模量的显微镜。 的结果予以 研究将提供新的信息，改进配方的酸性 如何用底漆处理脱矿牙本质， 良好的底漆树脂渗透塌陷或膨胀的脱矿牙本质，和 如何密封和保护胶原纤维。 结果也将 为模拟管间渗透特性提供了数据 以及管状牙本质。

DESCRIPTION (Adapted from the investigator's Abstract): Dentin bonding generally involves the use of acid conditioners to remove the smear layer and demineralize the dentin surface to expose the underlying collagen fibers of the intertubular dentin matrix. This demineralized matrix has such a low modulus of elasticity that it can collapse if allowed to air-dry, a common clinical procedure. As it collapses, the spaces between the collagen fibers are thought to become progressively smaller and presumably less permeable, yet it is through these channels that resins must diffuse during resin bonding. If the modulus of elasticity of the demineralized matrix can be increased above a critical value, the network may not collapse when air dried, thereby remaining permeable to resin monomers. A variety of procedures will be evaluated for the ability to stiffen demineralized dentin matrix. Thus far, no one has developed quantitative methods to measure the permeation of resin into demineralized dentin. The permeability of demineralized dentin to resins in wet versus dry matrices will be measured. Dry collapsed fiber networks are thought to be less permeable to resin monomers than wet, expanded networks. The proposed studies will test that hypothesis. The effects of different acid conditioners on the permeability, tensile properties, dimensions and solubility of collagen will be tested on both demineralized dentin and tendon as examples of insoluble collagen matrices. Several different salt additives to the acidic conditioners will be evaluated to see which ones best protect collagen from denaturation. Little is known about the stability of demineralized dentin matrix over time in water. The long-term stability of demineralized dentin matrix, with or without resin infiltration, in aqueous and nonaqueous solutions, will evaluate concerns about possible hydrolytic degradation of the matrix and loss of tensile properties over time. These macroscopic results will be re-examined at the microscopic level using both SEM and an atomic force microscope modified to measure modulus of elasticity. The results of these studies will provide new information on improved formulations of acidic conditioners, how demineralized dentin should be treated with primers, how well primer resins penetrate collapsed or expanded demineralized dentin, and how well they seal and protect the collagen fibers. The results will also provide data for modeling the permeability characteristics of intertubular as well as tubular dentin.