STARTLE PLASTICITY

精神分裂症的症状，强迫症（OCD）， 抽动秽语综合征部分原因是感觉运动门控缺陷。 被诊断患有这些疾病的患者前脉冲不足 抑制（PPI）（感觉运动门控的测量）。 此外，本发明还 精神分裂症患者有惊人的居住缺陷。 血清素 系统已被牵连的病理生理和机制 对这些疾病的治疗作用。 更好地理解 调节PPI和居住的神经机制（两种形式的 惊吓可塑性）可以允许开发更好的治疗方法。 本项目旨在研究突触前和突触后的作用， 5-羟色胺-1B（5-HT1B）受体和特定的神经回路 调节PPI和习惯化。 5-HT1B受体调节活性 多巴胺，血清素和GABA神经元的神经元， 调节PPI。

The symptoms of schizophrenia, obsessive-compulsive disorder (OCD), and Tourette's syndrome result in part from sensorimotor gating deficits. Patients diagnosed with these disorders have deficient prepulse inhibition (PPI) (a measure of sensorimotor gating). Additionally, schizophrenia patients have startle habitation deficits. The serotonin system has been implicated in both the pathophysiology and the mechanism of action of therapeutics for these disorders. A better understanding of the neural mechanisms that modulate PPI and habitation (two forms of startle plasticity) could permit the development of better treatments. This project proposes to investigate the role of pre- and postsynaptic serotonin-1B (5-HT1B) receptors and specific neural circuits in modulating PPI and habituation. 5-HT1B receptors regulate the activity of dopamine, serotonin, and GABA neurons that have been shown to modulate PPI.