CONFORMATION AND DYNAMICS OF POLYSACCHARIDES

描述（改编自摘要）：建议使用以下方法： 物理化学研究的形状，运动和相互作用， 寡糖和多糖，一类分子， 重要，有时被忽视。 基本前提是认识到生物学上重要的 碳水化合物的构象可能是一个不同的，也许是大的， 一组概率几乎相等的分子形状。球状体不是 已知，但二级结构是常见的，通常具有生物学意义。 基于计算机的分子建模用于寻求有用的近似， 碳水化合物构象能表面决定了 平衡分子形状分布。使用统计力学 来描述许多可接近的分子态对 分子的物理可观察性质。这些理论方法 通过设计实验来验证理论模型。核 磁共振技术探测形状和分子动力学。 辐射散射技术可用于表征无规线圈， 有序的形式。扫描探针显微镜和流变仪都是有效的 分子相互作用的探针，有助于稳定 生物活性形式。

DESCRIPTION (Adapted from abstract): It is proposed to use the methods of physical chemistry to investigate the shapes, motions, and interactions of oligosaccharides and polysaccharides, a class of molecules that is both important and sometimes neglected. The fundamental premise is the recognition that the biologically important conformations of carbohydrates may be members of a diverse, perhaps large, group of nearly equally probable molecular shapes. Globular forms are not known, but secondary structure is common and often of biological significance. Computer based molecular modeling is used to seek useful approximations to the carbohydrate conformational energy surfaces that determine the characteristics of the equilibrium molecular shape distribution. Statistical mechanics is used to describe the contributions from many accessible molecular states to the physically observable properties of the molecules. These theoretical approaches are complemented by experiments designed test the theoretical models. Nuclear magnetic resonance techniques probe both shape and molecular dynamics. Radiation scattering techniques are useful to characterize random coil and ordered forms. Scanning probe microscopy and rheometry are both effective probes of the molecular interactions that contribute to stabilize the biologically active forms.