SARCOIDOSIS GENETIC LINKAGE CONSORTIUM

结节病是一种病因不明的全身性肉芽肿性疾病，可能与遗传易感宿主中的某些环境因素有关。我们建议确定结节病的易感基因，并确定这些基因和环境风险因素如何相互作用而导致结节病。这将通过组织一个十中心多中心联盟招募足够的结节病家系样本进行分析来实现。我们计划使用受影响的同胞对连锁分析来扫描基因组以寻找相连的染色体区域，传递不平衡测试来评估那些具有连锁证据的区域中的候选基因，并使用环境问卷来收集数据来测试易感基因与外源性危险因素可能的相互作用。

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure to some environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how these genes and environmental risk factors interact to cause sarcoidosis. This will be accomplished by organizing a ten center multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis. We plan to use affected sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors.