CORE--CLINICAL

结节病是一种病因不明的全身性肉芽肿性疾病，可能与遗传易感宿主暴露于环境因子有关。我们建议确定结节病易感基因，并确定这些基因和环境危险因素如何相互作用，导致结节病。这将通过组织一个多中心联盟来完成，以招募足够的结节病家族样本进行分析。我们计划使用受影响的同胞对连锁分析来扫描基因组中的连锁染色体区域，传播不平衡测试来评估这些区域中的候选基因与连锁证据，以及环境问卷来收集数据以测试易感基因与外源性风险因素可能的相互作用。

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure toms environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how these genes and environmental risk factors interact to cause sarcoidosis. This will be accomplished by organizing a multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis. We plan to use affected sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors.