CHIRAL CONJUGATED POLYMER BASED SENSORS

描述：（主要研究者） 新型光电传感器的研究 手性有机化合物和药物的对映选择性识别 分子已经提出。这些传感器是通过使用 光学活性联萘基主链手性共轭 材料.不同的分子受体如冠醚， 聚铵大环和二硼酸官能团将是 结合到手性共轭聚合物中。这些材料将 可用于分析分子，如手性胺、氨基酸、手性 磷酸盐、手性羧酸盐、手性醇和糖。由于 这些新的共轭聚合物的手性，他们将能够 区分底物的对映体。综合研究 的联萘基手性共轭树枝状大分子也提出了。在 除了研究主链稳定的手性聚合物外， 构型，我们还建议制备非手性交叉共轭 聚合物，可以表现出主链手性存在下的手性 客人 这种诱导的主链手性将用于区分 手性分子的对映异构体。通过研究这些共轭 手性主体聚合物，它有望开发一类高度 具有快速响应的灵敏和对映选择性传感器。的 这些传感器与衬底的相互作用将通过 分析它们的紫外-可见吸收、荧光、磷光、CD 影响和电化学。这项研究将带来全新的 科学和重要的实际应用。

DESCRIPTION: (Principal Investigator's) The study of novel electrical and optical sensors for the enantioselective recognition of chiral organic compounds and drug molecules has been proposed. These sensors are constructed by using optically active binaphthyl-based main chain chiral conjugated materials. Different molecular receptors such as crown ethers, polyammonium macrocycles and diboronic acid functions will be incorporated into the chiral conjugated polymers. These materials will be used to analyze molecules such as chiral amines, amino acids, chiral phosphates, chiral carboxylates, chiral alcohols and sugars. Due to the chirality of these novel conjugated polymers, they will be able to differentiate the enantiomers of the substrates. The synthesis and study of binaphthyl-based chiral conjugated dendrimers is also proposed. In addition to the research on the polymers with stable main chain chiral configuration, we also propose to prepare an achiral cross-conjugated polymer that can exhibit main chain chirality in the presence of chiral guests. This induced main chain chirality will be used to discriminate the enantiomers of chiral molecules. Through the study of these conjugated chiral host polymers, it is expected to develop a class of highly sensitive and enantioselective sensors with rapid responses. The interaction of these sensors with substrates will be investigated by analyzing their UV-vis absorptions, fluorescences, phosphorescences, CD effects and electrochemistry. This study will lead to fundamentally new sciences and important practical applications.