MECHANISMS OF VASODILATION IN PREGNANCY

描述（改编自申请人的摘要）：四个假设是 建议进行调查。 假设1. 妊娠大鼠的肾脏 NO合酶（NOS）的表达增加，这有助于 一氧化氮依赖性肾血管舒张与妊娠高滤过。 假设2. 内皮素（RES-701-1拮抗剂）活化增加 位于内皮上的B受体亚型有助于 妊娠大鼠NO依赖性肾血管舒张和高滤过。 假设3. 松弛素也有助于NO依赖性肾血管舒张 和超滤。 假设4. 松弛素有助于 妊娠妇女肾血管舒张、高滤过和血管调节功能的变化 妇女

DESCRIPTION (Adapted from the applicant's abstract): Four Hypotheses are proposed for investigation. Hypothesis 1. The kidneys from gravid rats have increased expression of NO synthase (NOS), which contributes to the NO-dependent renal vasodilation and hyperfiltration of pregnancy. Hypothesis 2. Increased activation of the endothelin (RES-701-1 antagonist sensitive) B receptor subtype located on the endothelium contributes to NO-dependent renal vasodilation and hyperfiltration in gravid rats. Hypothesis 3. Relaxin also contributes to NO-dependent renal vasodilation and hyperfiltration in gravid rats. Hypothesis 4. Relaxin contributes to renal vasodilation, hyperfiltration, and osmoregulatory changes in gravid women.