GENETIC LINKAGE STUDY IN PARKINSONS DISEASE

描述（改编自研究者摘要） 特发性帕金森病（PD）是一种使人衰弱的疾病， 估计60岁或以上的人中有1%仍然未知。 研究 与该项目有关的调查人员和其他人已经 在PD的风险中表现出显著的家族性成分。 这 该提案是对国家计划公告的回应 神经疾病和中风研究所，要求研究 帕金森病的病因可能有遗传因素。 的目标 该项目将开始连锁研究，以定位易患帕金森病的基因 风险 为了鉴定含有与PD风险相关的基因的基因组区域， 研究人员提出了一个10厘摩密度的基因组扫描， 受影响的兄弟姐妹 参与者将通过一个 10个附属临床研究中心的多机构合作。 的400 受影响的同胞对将包括两组，每组200对。 基因组 扫描将在每组200个中单独进行，第二组 提供一种机制，以实现有希望的联系， 在第一组中发现的重要联系。 调查人员将评估 与发病年龄变异相关的可能遗传异质性 家族史和危险因素参与。

DESCRIPTION (Adapted from the Investigator's Abstract) The cause of Idiopathic Parkinson's disease (PD), a debilitating disease that afflicts an estimated 1 percent of persons age 60 or older, remains unknown. Research by investigators affiliated with this project and by others have demonstrated a significant familial component in the risk for PD. This proposal is in response to a Program Announcement from the National Institute of Neurological Disorders and Stroke, requesting research into possible genetic factors in the cause of Parkinson's disease. The goal of this project is to begin linkage studies to map genes which predispose to PD risk. To identify regions of the genome containing genes associated with PD risk, the investigators propose a 10 centimorgan density genome scan in 400 affected sibling pairs. Participants will be recruited through a multi-institutional collaboration of ten affiliated clinical sites. The 400 affected sib pairs will consist of two sets of 200 pairs each. The genome scan will be done separately in each set of 200, with the second set providing a mechanism for pursuing promising linkages and replicating significant linkages found in the first set. The investigators will assess possible genetic heterogeneity associated with variation in age at onset, PD family history, and risk factor involvement.