Molecular and cellular oncology program

描述：（申请人描述）分子和细胞肿瘤学项目（MCOP）是由以前的分子肿瘤学和细胞生物学项目融合而成的新项目。这个新项目汇集了匹兹堡大学医学院、匹兹堡大学生物科学系和卡内基梅隆大学（CMU）的顶尖分子和细胞肿瘤学家。MCOP的总体目标是在分子水平上探索人类肿瘤发生和发展的机制，并研究细胞过程中分子变化的功能输入。该计划成员由多学科的分子生物学家、细胞生物学家、生化学家、遗传学家和临床研究人员组成，他们研究实体瘤和造血恶性肿瘤中细胞周期调节、信号转导、基因转录、基因组改变和细胞生物学的基本方面。该项目由临时主任Paul D. Robbins博士（分子遗传学和生物化学系副教授）和Donald B. DeFranco（生物科学、神经科学和药理学系教授）领导。

Description: (Applicant's Description) The Molecular and Cellular Oncology Program (MCOP) represents a new program resulting from a fusion of the previous Molecular Oncology and Cell Biology Programs. The new program brings together the leading molecular and cellular oncologists at the University of Pittsburgh School of Medicine, the Department of Biological Sciences at the University of Pittsburgh, and Carnegie Mellon University (CMU). The overall objective of the MCOP is to explore the mechanisms underlying the onset and progression of human neoplasia at the molecular level linked to studies of the functional input of molecular changes on cellular processes. The Program membership is comprised of a multi-disciplinary group of molecular biologists, cell biologists, biochemists, geneticists and clinical researchers who study the fundamental aspects of cell cycle regulation, signal transduction, gene transcription, genomic alterations and cell biology in both solid tumor and hematopoietic malignancies. The Program is led by Interim Directors, Paul D. Robbins, Ph.D., an Associate Professor in the Department of Molecular Genetics and Biochemistry, and Donald B. DeFranco, a Professor in the Departments of Biological Sciences, Neuroscience and Pharmacology.