POPULATION GENETICS OF INTERACTIONS

我们的长期目标是提供一个统一的进化理论， 建立在群体遗传学原理上的相互作用。五个项目 这些建议都与这一总目标有关。首先，我建议研究 信息错误在性的起源和进化中的作用 周期本项目探讨了交替的起源和演变， 世代，这是真核生物生命周期的基础。二我 建议研究有害突变在进化中的作用， 生殖系统第三，我建议研究变异的作用， 适应性在交流进化中的作用。最近，一些假设 已经提出了有关的作用，健身变化在择偶 该项目旨在为评估提供一个共同框架， 这项工作第四，我建议研究近亲繁殖对 社会行为的演变以及社会行为对 近亲繁殖的进化第五，我建议研究体细胞的进化， 大脑中神经元之间相互作用的时间。通过结合 行为的进化和神经生物学方法，拟议的工作， 研究适应行为，无论是从最终的观点， 进化的因果关系，从神经元的近因观点来看， 机制等 拟议的工作之所以重要，原因如下。的问题 解决，性重组，动物交流，繁殖系统， 社会行为和大脑中的类别形成都是主要的 生物学中未解决的问题大多数人类疾病、病原体和寄生虫 在社会交往中传播。拟议的工作研究 这些相互作用对个体生物适应性的影响 以及这些影响是如何演变的。

Our long term objective is to provide a unified theory of the evolution of interactions built on the principles of population genetics. Five projects are proposed relating to this general goal. First, I propose studying the role of informational error in the origin and evolution of the sexual cycle. This project addresses the origin and evolution of alternation of generations, which is basic to the life cycle of eukaryotes. Second, I propose studying the role of deleterious mutation in the evolution of reproductive systems. Third, I propose studying the role of variation in fitness in the evolution of communication. Recently, several hypotheses have been advanced concerning the role of fitness variation in mate choice and this project seeks to provide a common framework for the evaluation of this work. Fourth, I propose studying the effect of inbreeding on the evolution of social behavior and the effect of social behavior on the evolution of inbreeding. Fifth, I propose studying the evolution in somatic time of interactions between neurons in the brain. By combining both the evolutionary and neurobiological approaches to behavior, the proposed work studies adaptive behavior both from the point of view of ultimate or evolutionary causality and from the proximate point of view of neuronal mechanisms. The proposed work is important for the following reasons. The problems addressed, sexual recombination, animal communication, breeding system, social behavior, and category formation in the brain, are all major unsolved problems in biology. Most human diseases, pathogens and parasites are transmitted during social interactions. The proposed work studies the effects of these interactions on the biological fitnesses of individuals and how these effects have evolved.