AFFECTIVE DISORDERS--AN EXPLORATION OF LONG TERM COURSE

描述(申请人摘要)：1978至1981年间，NIMH 协作性抑郁症研究对以下方面进行了彻底的基线评估 955名有严重情感障碍的先证者。先驱们被跟踪在 每半年和每年间隔10年，保留率为70.1% 那些还活着的人。这一后续行动的进一步延长目前 目前正在进行中，到1996年底将有16年的全面后续行动。 然而，用于延长后续行动的U01赠款不包括支助 用于数据分析。爱荷华州中心的调查人员通过 R01机制，并利用三年的支持产生了18个裁判 描述情感性疾病10年病程的期刊文章 句号。我们现在寻求具有竞争力的更新，以分析来自18个国家的全部数据 好几年了。早些时候的CDS分析强调了指数周期的过程， 后续临床事件发生的时间和远期预后 基线测量的质量。自那以后，我们将重点转移到 前瞻性观察事件的时间和现象学以及总体 通过反复观察发现了明显的趋势。未来的性质是 可用的评估提供了前所未有的机会来描述 无偏向的重大情感障碍的长期病程 参加回忆远程事件的尝试。此外，新推出的 统计方法将允许评估治疗效果 发病率和自杀风险。

DESCRIPTION (Applicant's Abstract): Between 1978 and 1981, the NIMH Collaborative Depression Study conducted thorough baseline evaluations of 955 probands with major affective disorder. Probands were followed at semiannual and annual intervals to 10 years with a retention rate of 70.1% of those still living. A further extension of this follow-up is currently underway and a full 16-year follow-up will be available by the end of 1996. The U01 grant for the extended follow-up, however, did not include support for data analysis. Investigators at the Iowa Center obtained this through the R01 mechanism and used the three years of support to produce 18 refereed journal articles describing the course of affective illness over a 10-year period. We now seek a competitive renewal to analyze data from the full 18 years. Earlier CDS analyses have emphasized the course of index episodes, the time to subsequent clinical events, and the long-range prognostic qualities of baseline measures. We have since shifted emphasis to the timing and phenomenology of prospectively observed episodes and to overall trends apparent across repeated observations. The prospective nature of the available assessments provides unprecedented opportunities to describe the long-term course of the major affective disorders without the biases attending attempts to recall remote events. Moreover, newly available statistical methods will allow the assessment of treatment effects on morbidity and risk for suicide.