EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

维克森林大学医学院（WFUSM）是一所国际性的 在利用非人类灵长类动物研究人类疾病方面处于领先地位。四 几十年来，我们一直利用非人类灵长类动物模型来研究生物学。 不同疾病状态的基础，包括动脉粥样硬化， 骨质疏松症、药物滥用、衰老和外周神经损伤。超过 在过去的五年里，WFUSM已经调整了功能成像 技术正电子发射断层扫描（PET）研究神经生物学 与非人类灵长类动物的行为相关。该计划包括 放射科系教师的跨部门努力， 生理学和药理学，比较医学，麻醉学和 神经生物学与解剖学。将PET成像纳入行为 灵长类动物慢性病模型的研究是独一无二的。快速增长 该计划反映了这种方法的独特性， 这项研究对NIH的使命的重要性。然而，这一增长也 限制了我们支持其他NIH资助的科学项目的能力， 导致非人类灵长类动物的运输增加 在WFUSM的三个不同的校区。的目标 校外科研设施建设项目是1）巩固 在行为研究中使用PET的研究者的研究计划 采用人类疾病的非人灵长类动物模型的程序; 2）提供 一个机制，将促进创新使用PET的其他 WFUSM的研究人员，3）允许其他非人类灵长类动物的生长， 利用不同神经生物学行为相关性的研究，以及4） 通过限制跨校区，确保PET研究的科学完整性 将猴子运送到PET中心。

The Wake Forest University School of Medicine (WFUSM) is an international leader in the use of non-human primates to study human disease. For four decades we have utilize non-human primate models to study the biological basis of diverse disease states, including atherosclerosis, oestopathology, substance abuse, aging, and peripheral nerve injury. Over the past five years, the WFUSM has adapted the functional imaging technique Positron Emission Tomography (PET) to study the neurobiological correlates of behavior in non-human primates. This program incorporates cross-departmental efforts of faculty in the Departments of Radiology, Physiology & Pharmacology, Comparative Medicine, Anesthesiology and Neurobiology & Anatomy. The incorporation of PET imaging into behavioral studies of primate models of chronic disease is unique. The rapid growth of this Program reflects the uniqueness of this approach and the importance of this research to the NIH mission. However, this growth also has limited our ability to support other NIH-funded scientific programs, and has resulted in an increased transportation of non-human primates across the three separate campuses of the WFUSM. The goals of the Extramural Research Facilities Construction Project are to 1) consolidate the research programs of investigators using PET in behavioral research programs employing non-human primate models of human disease; 2) provide a mechanism that will facilitate the innovate use of PET by other investigators at the WFUSM, 3) allow the growth of other non-human primate studies utilizing different neurobiological correlates of behavior, and 4) insure the scientific integrity of PET studies by limiting intercampus transportation of monkeys to the PET Center.