NEUROPHARMACOLOGY OF COCAINE AND SEROTONIN IN MONKEYS

十多年来，可卡因滥用一直是一个长期存在的问题。 尽管人们努力了解可卡因上瘾的基础 特性，没有药物疗法被证明对人类有效 使用。抑制关键大脑奖赏回路中的多巴胺摄取 与可卡因的行为刺激剂和 增强效果。脑的药理操作 5-羟色胺活性可以调节可卡因的行为特征 效果。拟议的研究试图刻画出 选择性5-羟色胺能药对行为的影响及强化作用 可卡因和选择性多巴胺摄取抑制剂GBR的作用 12909，在松鼠猴子身上。此外，中国的微透析研究 清醒，行为正常的松鼠猴将提供一种独特的方法 要理解行为与行为之间的关系 可卡因自我管理的后果和同时发生的变化 研究可卡因行为影响的大脑神经化学。 对大脑5-羟色胺和5-羟色胺相互作用的洞察 多巴胺系统将有助于理解可卡因滥用 以及许多其他疾病，如精神分裂症和 抑郁症被认为涉及到这些功能缺陷 系统。

Cocaine abuse has been a persistent problem for over a decade. Despite efforts to understand the basis of cocaine's addictive properties, no pharmacotherapies have proven efficacious for human use. Inhibition of dopamine uptake in key brain reward circuits has been strongly linked to cocaines' behavioral-stimulant and reinforcing effects. Pharmacological manipulations of brain serotonin activity can modulate cocaine's profile of behavioral effects. The proposed studies seek to characterize the effects of selective serotonergic agents on the behavioral and reinforcing effects of cocaine and the selective dopamine uptake inhibitor, GBR 12909, in squirrel monkeys. Furthermore, microdialysis studies in awake, behaving squirrel monkeys will provide a unique approach to understanding the relationship between the behavioral consequences of cocaine self-administration and concurrent changes on brain neurochemistry that underlie cocaine's behavioral effects. Insights gained into the interactions between brain serotonin and dopamine systems will aid the understanding of cocaine abuse as well as numerous other conditions such as schizophrenia and depression which are believed to involve functional defects in these systems.