FUNCTIONAL ANALYSIS OF BRCA1

乳腺癌基因BRCA 1最近被克隆，并被鉴定为一种 肿瘤抑制基因 最近发现BRCA 1结合于 DNA修复蛋白Rad 51和BRCA 1也可能对DNA损伤做出反应。 本提案的总体目标是了解 BRCA 1/Rad 51相互作用。 具体而言，研究将调查 这些复合物的生物化学性质，DNA损伤如何影响它们的 BRCA 1/Rad 51复合体的功能意义 功能 预计这种增加的了解将产生 对肿瘤发生的深入了解， 乳腺癌的诊断和治疗。

The breast cancer gene, BRCA1 was recently cloned an identified as a tumor suppressor gene. It was recently revealed that BRCA1 binds to the DNA repair protein, Rad51 and that BRCA1 may also respond to DNA damage. The overall goal of this proposal is to gain an understanding of BRCA1/Rad51 interaction. Specifically, the research will investigate the biochemical nature of these complexes, how DNA damage effects their association and the functional significance of the BRCA1/Rad51 complex function. It is expected that this increased understanding will yield insights into oncogenesis with ultimate therapeutic implications for the diagnosis and treatment of breast cancer.