ANTICANCER AGENTS FROM UNIQUE NATURAL PRODUCTS SOURCES

该计划的基本主题是整合发现 新的生物活性天然产物， 独特的生态位与机制导向的癌症生物学。的 总体目标是鉴定临床上有用的药物， 靶向人实体瘤疾病和由其引起的相关感染 免疫缺陷PI，爱尔兰博士将负责 项目管理，包括财务管理， 协调各群体之间的沟通， 数据，跟踪优先线索并安排与NIH的会议 官员爱尔兰博士还将监督天然产品子项目 用于海洋无脊椎动物的化学研究， 相关微生物克雷默医生将负责药物 这个计划的发展方向。这将包括初步测试 由Cyanamid的天然产品集团提供的样品 肿瘤药物筛选（CODS），作用机制研究，动物 毒理学和动物模型中的体内抗肿瘤研究。克雷默博士 还将监督免疫刺激试验中的样本测试。博士 Maiese将监督一个研究海洋微生物的子项目， 有机体将特别强调微生物 从特定的环境中获得。迈斯博士的团队将 负责分离、分类鉴定和发酵 微生物的数量克拉迪医生将监督一个天然产品 新植物内生真菌研究子程序和一个较小的努力 关于通过X射线衍射对铅进行表征。安德森博士 将监督一个研究海洋生物的天然产品子项目， 无脊椎动物和相关微生物。

The underlying theme of this program is to integrate discovery of novel biologically active natural products from organisms that inhabit unique ecological niches with mechanism-directed cancer biology. The overall goal is the identification of clinically useful drugs that target human solid tumor diseases and related infections caused by immune deficiency. The PI, Dr. Ireland will be responsible for administration of the program, including financial management, orchestrating communication between the groups and dissemination of data, tracking of priority leads and arranging meetings with NIH officials. Dr. Ireland will also oversee a natural products subprogram for studies of the chemistry of marine invertebrate animals and associated microorganisms. Dr. Kramer will be responsible for the drug development aspect of this program. This will include initial testing of samples supplied by the natural products groups in Cyanamid's Oncology Drug Screen (CODS), mechanism of action studies, animal toxicology and in vivo antitumor studies in animal models. Dr. Kramer will also oversee testing of samples in immune stimulation assays. Dr. Maiese will oversee a subprogram for studies of marine micro- organisms. Particular emphasis will be placed on micro-organisms obtained from specific environments. Dr. Maiese's group will be responsible for isolation, taxonomic identification and fermentation of subject micro-organisms. Dr. Clardy will oversee a natural products subprogram for studies of novel endophytic fungi and a smaller effort on the characterization of leads by X-ray diffraction. Dr. Andersen will oversee a natural products subprogram for studies of marine invertebrate animals and associated microorganisms.