UROLOGICAL RESEARCH TRAINING FOR BASIC SCIENTISTS

该提案支持培养博士后科学家，使其成为致力于研究泌尿生殖系统疾病的独立研究人员。该计划是协调和共同管理的一个类似的努力培训委员会合格的泌尿科医生在泌尿外科调查。培养一个小的，但高素质的博士子集。科学家从事与泌尿生殖系统疾病有关的当代研究是一项投资，对国家当前和未来的卫生保健需求至关重要。肾脏和泌尿生殖系统疾病影响了1300多万美国人，而且这个数字在不久的将来可能会增加。我们的培训计划培养科学家，他们可以通过适当地配备现代研究工具和有效的知识基础来应对这一医学挑战，以便他们能够解开泌尿生殖系统疾病的机制。细胞和分子生物学的实验工具和知识发现为预防、治疗和控制以及在某些情况下治愈泌尿生殖系统疾病创造了令人兴奋的新可能性。该培训计划是为适应学员从不同的学术背景：正式指令是在生物统计学，细胞生物学和重组DNA技术，生产全面，跨学科的科学家的目标可用。由临床研究人员和基础科学家组成的协调小组在特定兴趣领域进行具体指导，确保了与研究培训并行的跨学科发展。所有导师都在医学院拥有终身或终身职位，至少有一项积极的研究资助，并有培训博士后科学家从事生产性职业的经验。机构环境提供了丰富的研讨会，客座教授和会议，刺激学员和导师之间的交流。教师研究计划的主要重点包括：平滑肌挛缩的分子生理学和药理学，睾丸及其流出道的病理生理学，前列腺生长控制和癌症，阻塞性疾病的神经泌尿学，生长因子在神经肌肉相互作用中的作用，泌尿生殖系统疾病和阻塞性肾脏病理的神经，血管和免疫机制。跨学科培训基础科学家在有前途的研究相关的泌尿疾病遵循弗吉尼亚大学医学院的承诺，以促进临床研究人员和基础科学家的生产共同点，利用新的研究在泌尿外科的关键疾病机制。

This proposal support for the training of post-doctoral scientists for careers as independent investigators committed to studying diseases of the genitourinary system. The program is coordinated and co-administered with a similar effort training board-eligible urologists in urological investigation. Training of a small but highly qualified subset of Ph.D. scientists to pursue contemporary research relevant to diseases of the urogenital system is an investment that is essential to the nation's current and future health care needs. Diseases of the kidneys and urogenital system affect more than 13 million Americans and this number may increase in the near future. Our training program develops scientists who can meet this medical challenge by equipping them appropriately with modern research tools and an effective knowledge base so they can unravel the mechanisms of urogenital disorders. The experimental tools and intellectual discoveries of cell and molecular biology have generated exciting new possibilities for the prevention, treatment, and control and, in some cases, cure of afflictions of the genitourinary system. The training program is tailored to accommodate trainees from diverse from diverse academic backgrounds: formal instruction is available in biostatistics, cell biology, and recombinant DNA technology with the goal of producing well-rounded, inter- disciplinary scientists. Specific mentoring by coordinated teams of clinician-investigators and basic scientists in specific interest areas ensures cross-disciplinary development in parallel with research training. All mentors hold tenured or tenure-track appointments in the School of Medicine, direct at least one active research grant, and have experience in training postdoctoral scientists for productive careers. The institutional environments offers a rich mixture of seminars, visiting professors and conferences that creatures stimulating exchanges among trainees and mentors. The primary focus of faculty research programs includes: molecular physiology and pharmacology of smooth muscle contracture, pathophysiology of the testis and its excurrent ducts, prostate growth control and cancer, neuro-urology of obstructive disorders, role of growth factors in neuromuscular interaction, neural, vascular and immunological mechanisms of urogenital disease and obstructive renal pathology. Interdisciplinary training of basic scientists in promising research relevant to urological disease follows the University of Virginia Medical School's commitment to foster a productive common ground for clinical investigators and basic scientists to exploit novel research in critical disease mechanisms in urology.