HIV, TB, HSV 2--EMERGENCE OF DRUG RESISTANCE

描述(改编自摘要)：本报告的总体目标 项目是开发数学模型并将其应用于设计控制 同时降低发病率和死亡率的战略 在控制疟疾流行时减少抗药性的影响 人类免疫缺陷病毒(HIV)、结核分枝杆菌(TB)和 单纯疱疹病毒2型(HSV-2)。该项目汇集了一个社区 包括数学模型师和传染性研究人员在内的研究人员 疾病专家。其目的是(1)制定一系列疾病 反映病毒传播动态的特定数学模型 治疗人群中的药物敏感和抗药性病原体，(2) (A)预测耐药性的发生率和流行率，以及(B)确定 哪种生物、行为或治疗因素在 导致耐药性的出现和传播，以及 (3)(A)设计控制战略，(B)制定评价标准，以及8 使用标准来评估医疗和行为之间的权衡 在设计和改进控制策略时的干预措施。艾滋病毒控制 将为感染艾滋病毒的同性恋社区制定战略， 除了疫苗，还使用了联合疗法。电视控制策略 是基于疫苗接种、化学预防、慢性抑制和 潜在的疫苗。研究人员还将考虑潜在的 如果艾滋病毒流行导致发病率、死亡率和 对TV和HSV-2的抗药性水平。

Description (adapted from the Abstract): The overall objective of this project is to develop and apply mathematical models to design control strategies that will reduce morbidity and mortality while simultaneously reducing the impact of drug resistance when controlling epidemics of the human immunodeficiency virus (HIV), Mycobacterium tuberculosis (TB), and herpes simplex virus-2 (HSV-2). The project brings together a community of researchers that includes both mathematical modelers and infectious disease experts. The aims are to (1) formulate a series of disease specific mathematical models that reflect the transmission dynamics of drug-sensitive and drug-resistant pathogens in a treated population, (2) (a) predict incidence and prevalence of drug resistance, and (b) identify which biological, behavioral, or treatment factor are most important in contributing to the emergence and transmission of drug resistance,, and (3) (a) design control strategies, (b) develop evaluation criteria, and 8 use the criteria to evaluate tradeoffs among medical and behavioral interventions when designing and improving control strategies. HIV control strategies will be designed for HIV-infected gay communities in which combination therapies are used, as well as vaccines. TV control strategies are based on vaccinations, chemoprophylaxis, chronic suppression, and potential vaccines. The researchers will also consider the potential effects if the HIV epidemic on causing increased morbidity, mortality, and levels of drug resistance to both TV and HSV-2.