EPIDEMIOLOGY OF PHYSICAL ACTIVITY AND OVARIAN FUNCTION

剧烈的体能训练，独立的或联合的 体重、身体成分和/或能量摄入量等因素是 与卵巢功能的各种紊乱有关，包括 少/闭经，黄体期缩短，卵泡期延长， 无排卵，并降低孕酮和雌激素。这些改动 可能会对乳房和其他方面产生有益的影响 生殖癌，但对骨骼健康有负面影响。 卵巢破裂的程度与 娱乐和职业活动，通常见于人群中 在逃的人还不是很清楚。这项提案是针对一系列 流行病学研究将检查身体健康的影响 活动对月经周期、生殖功能的影响 荷尔蒙模式和激素相关症状使用三种不同的 数据集。第一个数据集来自 半导体健康研究，一项关于不良风险的大型研究 从事硅片制造的女性的生殖结局 植物。样本由402名不同种族的女性组成，她们是 在基线上接受采访，并完成每日日记并收集 长达六个月的每日尿液样本。第二个数据集来自 一项以社区为基础的女性骨健康纵向队列研究 密歇根州特库姆塞(N=583)。四年来，体力活动的数据， 收集体重、身体成分、饮食摄入量和症状 每年一次，月经每月一次。的纵向性质 此数据集允许检查以下之间的关系 活动的改变和月经功能和症状的改变 时间，考虑到体重、身体成分和 饮食因素。最后，饮食与经前状态的病例对照研究 102例患者和102名配对对照在 北加州Kasier Permanente医疗保健计划提供数据 用于评估与活动相关的经前综合症的诊断风险。 数据将使用横截面和纵向分析进行评估 技巧。通过加深对两国关系的理解 在人群水平上的体力活动和卵巢功能，这 拟议的研究将有助于更好地了解这些好处 和体力活动对女性生殖和整体健康的风险 健康。

Vigorous physical training, either independently or in conjunction with factors such as weight, body composition and/or energy intake, is associated with various disruptions in ovarian function, including oligo/amenorrhea, shortened luteal phase, lengthened follicular phase, anovulation, and decreased progesterone and estrogen. These alterations may have beneficial consequences in terms of breast and other reproductive cancers, but negative consequences in terms of bone health. The extent to which ovarian disruption is associated with the recreational and occupational activity typically seen in the population at large is not well known. This proposal is for a series of epidemiological studies that will examine the influence of physical activity on characteristics of the menstrual cycle, reproductive hormonal patterns, and hormone-related symptoms using three different datasets. The first dataset is from the prospective component of the Semiconductor Health Study, a large study of the risk of adverse reproductive outcomes among women working in silicon wafer manufacturing plants. The sample consists of 402 ethnically diverse women who were interviewed at baseline and who completed daily diaries and collected daily urine specimens for up to six months. The second dataset is from a community-based longitudinal cohort study of bone health in women from Tecumseh, Michigan (N=583). For four years, data on physical activity, weight, body composition, dietary intake, and symptoms were collected annually and menstrual calendars monthly. The longitudinal nature of this dataset allows for an examination of the relationship between change in activity and change in menstrual function and symptoms over time, taking into account the influence of weight, body composition and dietary factors. Finally, a case-control study of diet and premenstrual syndrome with 102 cases and 102 matched controls conducted at the Northern California Kasier Permanente Medical Care Program provides data for an evaluation of the risk of diagnosed PMS associated with activity. Data will be evaluated using cross-sectional and longitudinal analytic techniques. By furthering understanding of the relation between physical activity and ovarian function at the population level, this proposed study will contribute to a better understanding of the benefits and risks of physical activity for women's reproductive and overall health.