EYE/HAND COORDINATION BY CEREBELLAR OUTPUT NEURONS

我们的长期目标是了解小脑在 对伸手抓住物体的控制。抓住一个物体的触角是一种 基本动作用于日常活动和生产的协调 伸手抓握高度依赖于小脑功能。分析 小脑参与触觉掌握会带来更好的效果 了解或组织整个马达系统，并可 为假体装置的设计提供有价值的指导 补偿受损的运动控制。 我们已经发现，小脑回路是专为 控制一个要抓住的触角。简单的前肢动作不会 激活小脑回路，但伸展和 握力会引起高的神经放电频率。我们还发现 小脑的区域专门用于控制特定的 要抓住组件的触角。肢体相关小脑输出神经元 只参与抓取组件的控制，而不参与 运动的运输组件。 为了准确实现其行为目标而抓住的触角，GRAS- 相关的控制信号需要与视觉信息相结合 关于待处理对象的空间位置和外部特征 抓住了。这需要眼睛和肢体之间的精确协调- 相关的神经网络。构成的基础的工作假设 拟议的实验是，小脑是大脑 神经底物是这种协调的基础。具体地说， 实验将验证眼球运动与小脑输出有关的想法 位于后间隙腹侧及其邻近的神经元 腹侧齿状核的部分为肢体相关神经网络提供 关于要抓取的目标的空间位置的信息 对于河段的运输部分来说，这是至关重要的 准确。

Our long-range goal is to understand the role of the cerebellum in the control of reaching to grasp an object. The reach to grasp an object is a basic movement used in daily activities and production of a coordinated reach to grasp is highly dependent upon cerebellar function. Analyzing cerebellar participation in the reach to grasp will lead to much better understanding or the organization of the entire motor system and may provide valuable guidance to the design of prosthetic devices attempted to compensate for impaired motor control. We have discovered that cerebellar circuitry is specialized for the control of a reach to grasp. Simple movements of the forelimb do not activate cerebellar circuitry, but the coordinated action of reaching and grasping elicits high rates of neural discharge. We have also discovered that regions of the cerebellum are specialized for the control of specific components of the reach to grasp. Limb-related cerebellar output neurons only participate in the control of the grasping component and not the transport component of the movement. For a reach to grasp to accurately accomplish its behavioral goal, gras- related control signals need to be integrated with visual information concerning the spatial location and external features of the object to be grasped. This requires precise coordination between eye-related and limb- related neural networks. The working hypothesis that forms the basis for the proposed experiments is that the cerebellum is a critical part of the neural substrate underlying such coordination. Specifically, the experiments will test the idea that eye movement-relate cerebellar output neurons located ventrolaterally in posterior interpositus and adjacent parts of ventral dentate nucleus provide limb-related neural networks with information concerning the spatial location of the target to be grasped that is critical for the transport component of the reach to grasp to be accurate.