ADHERENCE TO HIV THERAPIES IN DRUG USERS

描述：（申请人摘要）吸毒者对HIV治疗的依从性 在新奥尔良 该提案旨在探讨坚持新的艾滋病毒治疗方案 在有吸毒史的人群中， 路易斯安那州医疗中心（HOP）在新奥尔良的计划。 粘附 慢性药物治疗是一个重要因素，在修改 这些新疗法的有效性。 新型抗逆转录病毒复合药物 治疗有望将艾滋病毒转化为慢性疾病。 然而 抗逆转录病毒药物治疗方案的复杂性。 副作用. 和不断变化的 艾滋病患者群体可能会增加不依从的可能性 这些长期使用的药物 不幸的是，即使相对温和 不遵守某些联合治疗方案。 特别是 包括蛋白酶抑制剂，可能导致病毒耐药性，逆转 HIV I疾病进展和多种抗逆转录病毒药物无效 毒品 同样，在这方面也没有一个全面的遵守模式 或任何人口。 这项由杜兰大学在1999年进行的提案， 与路易斯安那州立大学和妇女与愿景， 非洲裔美国人社区组织，有与我合作的历史， 注射毒品者 是一个独特的努力，探索社会，文化和个人 导致遵守或不遵守的因素。 该项目将： 1)分析一个市中心的吸毒人口， 类似于我即将到来的一代艾滋病患者：2）使用混合 方法来证实遵守。 包括比较诊所和我 处方索赔数据和自我报告; 3）涉及民族志， 探索依从性问题;以及4）探索社交网络影响力 理论和社会网络分析方法来解释坚持 行为。

DESCRIPTION: (Applicant's Abstract) Adherence to HIV Therapy in Drug Users in New Orleans This proposal is designed to explore adherence to new HIV treatment regimens in a population with a history of drug use attending the HIV Outpatient Program of the Medical Center of Louisiana (HOP) in New Orleans. Adherence to chronic drug therapy is an important factor in modifying the effectiveness of these new treatments. New combination antiretroviral drug therapies promise to convert HIV into a chronic disease. Yet, the complexity of antiretroviral drug regimens. side effects. and the changing population of AIDS patients may increase the likelihood of non-adherence with these chronically-used drugs. Unfortunately, even relatively modest non-adherence with some of the combination regimens. particularly those which include a protease inhibitor, may lead to viral resistance, reversed progression of HIV I disease and ineffectiveness of multiple antiretroviral drugs. Equally, a comprehensive model of adherence does not exist for this or any population. This proposal, conducted by Tulane University in collaboration with Louisiana State University and Women with a Vision, an African-American community based organization with a history of work with I IDUs. is a unique effort to explore the social, cultural and personal factors which contribute to adherence or non-adherence. This project will: 1) analyze an inner-city drug-using population that is demographically similar to the I upcoming generation of AIDS patients: 2) use a mix of methods to corroborate adherence. including comparing clinic and i prescription claims data, and self-report; 3) involves ethnography in exploring adherence issues; and 4) explores social network influence theories and social network analysis methods to account for adherence behaviors.