IN VIVO ULTRASONIC MICROPROBE FOR TUMOR DIAGNOSIS

这项为期两年的倡议的目标是为 固体的临床原位诊断的全新技术 期望快速、准确地检测和诊断的肿瘤 癌症的威胁。研究方法是跨学科的(声学和 电子工程师、图像和信号处理器、材料科学家和 委员会认证的兽医病理学家)。考虑到重要的住院病人 获得高准确度和及时性诊断的保健管理 以及相关的困难、处理时间和风险 通过手术和抽吸活组织检查，这项技术将允许 对原位肿瘤的评估在医学上是非常有益的。 而且性价比高。 这项为期两年的倡议的具体目标是：(1)确定 分化组织和细胞的超声图像特征 部分肿瘤正常组织的细胞构筑特征 使用成熟的非侵入性脉冲回波数据采集组织 高清晰度成像方案和技术适用于 有创性体内超声微探头几何结构，(3)构建和 用两种不同的方法评价有创性体内超声微探头 构造方法；(4)超声图像特征识别 分化正常组织和细胞结构特征的组织和细胞 利用体内侵袭性技术从选定的肿瘤组织中提取组织 超声波微探头。卵巢癌光镜组织病理学评价 由委员会认证的兽医病理学家提供的相同组织将是 被用作黄金标准。 提出了三种类型的超声数据采集，即非超声数据采集和非超声数据采集 侵入性使用商用传感器；侵入性微探头使用现有的， 商业上可获得的材料；以及使用新的侵入性微探针 开发的材料。常规B型和C型成像技术 将会被调查。此外，还提出了自适应信号 合成孔径雷达(SAR)成像处理技术 技巧。此外，还将测试图像形成和增强方法 并基于成熟的统计模型对刺激数据进行了验证 的超声成像处理，采用了增强版本的 标准全显影散斑模型。

The objective of this two-year initiative is to develop the basis for a fundamentally new technology for an in situ clinical diagnosis of solid tumors with the expectation of rapid and accurate detection and diagnosis of cancer. The research approach is interdisciplinary (acoustic and electrical engineers, image and signal processor, material scientists, and board-certified veterinary pathologist). Given the important in patient health-care management of obtaining a highly accurate and timely diagnosis of a tumor and the difficulties, processing time, and risks associated with surgical and aspirational biopsies, a technique which would permit the evaluation of tumors in situ would be enormously beneficial medically and cost effective. The specific aims of this two-year initiative are: (1) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using well-established non-invasive pulse-echo data acquisition schemes and high-definition image formation techniques applicable for the invasive in vivo ultrasonic microprobe geometry, (3) to construct and evaluate invasive in vivo ultrasonic microprobes using two separate construction approaches, and (4) to identify ultrasonic image features of tissues and cells that differentiate cytoarchitectural features of normal tissues from selected neoplastic tissues using the invasive in vivo ultrasonic microprobes. Light microscopic histopathologic evaluation of the identical tissues by a board-certified veterinary pathologist will be used as the gold standard. Three categories of ultrasonic data acquisition are proposed, viz., non- invasive using commercial transducers; invasive microprobe using existing, commercially available materials; and invasive microprobe using newly developed materials. Conventional B-mode and C-mode imaging techniques will be investigated. In addition, it is proposed to adapt signal processing techniques from synthetic aperture radar (SAR) imaging techniques. Also, image formation and enhancement methods will be tested and verified on stimulate data based on a full-fledged statistical model of the ultrasound imaging processing, adopting an enhanced version of the standard fully-developed-speckle model.