CALCIUM SIGNALING

寻求资金用于支付戈登钙信号研究会议的部分支持，该会议将于1999年8月8日至13日在新英格兰学院亨尼克举行。这次会议为钙信号领域的思想和信息交流提供了一个独特的多学科论坛。由于钙信号是所有真核生物(从酵母到哺乳动物细胞)共同的基本细胞控制手段，会议通过刺激使用各种不同生物和细胞系统的工作人员交换有关细胞调节的基本信息来获得特别的力量。主要目标是促进新老调查人员之间的成功互动。将优先选择和提供资金，支持初级科学家(学生和博士后实习生)、女科学家和代表性不足的少数族裔科学家。会议将包括8个会议，包括研究报告和广泛的讨论，每个会议由一名在最大限度地进行互动交流方面经验丰富的该领域知名成员领导。大会还将由小詹姆斯·W·普特尼博士发表主旨演讲。是钙信号领域的先驱。此外，还将有两个海报研讨会，从海报演讲者中挑选出来的初级科学家有机会在主要会议期间口头介绍他们的工作。每一次计划的会议都将集中在钙信号的及时和核心方面，包括细胞内IP3受体的分子性质和调控，钙信号事件的空间和时间控制，线粒体在钙信号中的作用和作为细胞损伤和凋亡的媒介，脑和外周组织中钙信号的靶点，以及研究钙和其他细胞内离子的方法学的最新进展。参与者包括代表一系列细胞系统和不同技术的成熟和成功的年轻研究人员的组合，从钙信号机制的分子生物学分析和操作，到观察钙信号的产生和传播的尖端和开创性的显微成像技术。参与者的基础学科包括生物化学、生理学、细胞生物学、分子生物学、生物物理学、病理学和药理学；然而，所有参与者都对了解细胞内钙信号事件的机制和意义感兴趣。本次会议将讨论的议题对我们理解一些健康问题很重要，包括与环境健康、癌症生物学、囊性纤维化、糖尿病、神经退行性疾病和老龄化等相关的问题。

Funds are sought to cover partial support of the Gordon Research Conference on Calcium Signaling, to be held at New England College, Henniker, NH, August 8-13, 1999. The meeting provides a unique multidisciplinary forum for interchange of ideas and information in the field of calcium signaling. Since calcium signaling is a fundamental means of cellular control common to all eukaryotic organisms, from yeast to mammalian cells, the meeting derives particular strength by stimulating the interchange of basic information on cell regulation from workers using a rich variety of different organisms and cellular systems. The primary objective is to facilitate successful interactions between new and established investigators. Highest priority will be given to the selection and provision of funds to support junior scientists (student and postdoctoral trainees), women scientists, and under-represented minority scientists. The conference will include 8 sessions with research presentations and extensive discussion, each lead by a prominent member of the field with experience in maximizing interactive exchange. There will also be a keynote address given by Dr. James W. Putney, Jr. of MEHS, a pioneer in the calcium signaling field. In addition, there will be two poster sessions and opportunities for junior scientists selected from the poster presenters to make oral presentations of their work within the main sessions. Each of the planned sessions will focus on timely and central aspects of calcium signaling, including the molecular nature and regulation of intracellular IP3 receptors, the spatial and temporal control of calcium signaling events, the role of mitochondria in calcium signaling and as mediators of cell injury and apoptosis, targets of calcium signaling in the brain and in peripheral tissues, and recent advances in the methodology for studying calcium and other intracellular ions. Participants include a combination of established and successful younger investigators representing an array of cellular systems and different techniques ranging from molecular biological analysis and manipulation of the calcium signaling machinery to sophisticated and pioneering micro- imaging technology to observe the generation and propagation of calcium signals. Basic disciplines of participants include biochemistry, physiology, cell biology, molecular biology, biophysics, pathology and pharmacology; however, all have a primary interest in understanding the mechanisms and significance of calcium signaling events in cells. The topics to be addressed at this meeting are important to our understanding of a number of health problems, including issues related to environmental health, cancer biology, cystic fibrosis, diabetes, neurodegenerative diseases and aging, to name a few.