NEUROTOXICITY OF AMPHETAMINES AND RELATED STIMULANTS

这一年申请R13会议补助金的目的是为题为“苯丙胺及相关兴奋剂的神经毒性”的会议寻求部分支持。这次会议将于1999年4月16日至17日在华盛顿特区举行的实验生物学99会议(EB99)之前和同时举行。本次会议的赞助和部分支持也是通过参加EB99会议的六个协会之一的ASPET寻求的。这次会议将包括该领域主要研究人员的16个综合报告，与会者将来自对药物滥用感兴趣的神经化学家、神经药剂学家、毒物学家、分子生物学家、细胞生物学家和临床医生。会议的目标有四个方面：1)聚集该领域的主要研究人员，介绍他们关于苯丙胺神经毒素的最新发现；2)鼓励发言者和与会者在细胞和分子水平上就这些滥用药物的毒性作用机制进行综合讨论；3)以编辑书籍的形式出版最新的论文，最大限度地传播会议上提出的科学材料；以及4)满足公众的需要，增加对与滥用甲基苯丙胺和摇头丸(摇头丸)等神经毒性安非他明有关的问题的科学研究。将涵盖的主题包括苯丙胺的神经毒性和药理学的全面概述，药物对发育中的大脑的影响，神经递质系统和线粒体能量状态作为苯丙胺毒性的决定因素，活性氧物种，一氧化氮，醌和藜麦蛋白在神经元损伤中的作用，以及苯丙胺滥用对人类的长期后果。海报会议、圆桌讨论会以及出版一本书和期刊摘要文章将最大限度地向广大外地传播药物滥用这一重要方面的最新发展。

This single year application for an R13 Conference Grant is seeking partial support for a conference entitled "The Neurotoxicity of Amphetamines and Related Stimulants". The meeting will be held from 16-17 April, 1999, just prior to and in conjunction with the Experimental Biology 99 meeting (EB99) in Washington, DC. Sponsorship and partial support for this conference is also being sought through ASPET, one of six participating societies in the EB99 meeting. This conference will include 16 comprehensive presentations by leading investigators in the field, and the participants will be drawn from neurochemists, neuropharmacologists, toxicologists, molecular biologists, cell biologists, and clinicians with interest in drug abuse. The goals of the conference are four- fold 1) to bring together the leading investigators in the field for a presentation of their latest findings on the amphetamine neurotoxins, 2) to stimulate integrative discussions among speakers and attendees regarding the toxic mechanisms of action of these drugs of abuse at the cellular and molecular level; 3) to publish a state-of-the-art treatise in the form of an edited book to maximize dissemination of the scientific material presented at the conference; and 4) to serve the public need for increased scientific research into the problems associated with abuse of neurotoxic amphetamines such as methamphetamine and MDMA (Ecstacy). The topics to be covered include a comprehensive overview of amphetamine neurotoxicity and pharmacology, drug effects on the developing brain, neurotransmitter systems and mitochondrial energy status as determinants of amphetamine toxicity, the roles of reactive oxygen species, nitric oxide, quinones, and quinoproteins in neuronal damage, and long-term consequences of amphetamine abuse in humans. Poster sessions, round-table discussions, and publication of a book and journal summary article will maximize dissemination of the latest developments in this important aspect of drug abuse to the field at large.