SIMD ANNUAL MEETING--CONFERENCE GRANT

本申请书代表遗传代谢学会 精神障碍(SIMD)申请旅行支持以允许美国年轻人 调查人员将出席在拉尼尔湖举行的SIMD年会， 1999年3月13日至15日，格鲁吉亚。中间代谢的先天缺陷 (IEMS)越来越多地被认为是智力低下的原因， 神经肌肉疾病，心脏疾病，肝肾功能障碍， 关节炎、糖尿病、发育障碍和失明。这些条件 打击婴幼儿，从而影响年轻家庭。 这些先天偏误产生的原因和机制研究 新陈代谢改善了诊断，并导致了有效的治疗 这些条件有很多，但还有很多事情要做。这项研究 也导致了我们对基本知识的实质性增加 中间代谢、信号转导、中枢神经科学 系统功能、细胞内靶向和基本遗传机制。 这种知识的增长对于保持在 针对这些严重疾病的创新疗法。让美国继续留在美国 在这一重要的研究和临床应用领域表现卓越， 年轻的调查人员有机会 参加SIMD会议，在那里他们可以分享他们的工作和 为新的协作项目做出贡献。无与伦比的进步 对间质性肌萎缩侧索硬化症的分子和遗传学基础的理解 继续将这些知识应用于临床情况需要 美国青年的参与、发展和鼓励 调查人员。

This application is on behalf of the Society for Inherited Metabolic Disorders (SIMD) to request travel support to permit young US investigators to attend the annual meeting of the SIMD in Lake Lanier, Georgia, March 13-15, 1999. Inborn errors of intermediary metabolism (IEMs) are increasingly recognized as causal to mental retardation, neuromuscular disease, cardiac disorders, hepatic and renal dysfunction, arthritis, diabetes, growth failure, and blindness. These conditions strike infants and young children and thus affect young families. Research into the causes and mechanisms of these inborn errors of metabolism improved diagnosis and has led to effective treatment for many of these conditions, but there is much left to do. This research has also led to substantive increases in our knowledge of the basic science of intermediary metabolism, signal transduction, central nervous system function, intracellular targeting, and basic genetic mechanisms. This increase in knowledge is essential to maintain progress in innovative therapies for these severe disorders. For the US to remain pre-eminent in this important area of research and clinical application, it is essential that young investigators have the opportunity to participate in the SIMD meeting, where they can share their work and contribute to new collaborative projects. The unparalleled advances in the understanding of the molecular and genetic basis of IEMs and the continuing application of this knowledge to clinical situations demands the participation, development, and encouragement of young US investigators.