REGULATION OF METABOLISM BY HYPOXIA AND OSMOTIC PRESSURE

近年来，人们对结构组织有了很多了解， 和调节中间代谢的途径， 利什曼原虫的前鞭毛体形式，生活在肠道中， 白蛉。 对人体的新陈代谢知之甚少， 无鞭毛体形式，生活在人类巨噬细胞的吞噬溶酶体中， 引起利什曼病。 现在有可能培养出无鞭毛体形式的 墨西哥利什曼原虫pifanoi在无菌培养，这开辟了道路， 了解它的新陈代谢，研究它的连续变化， 从一种形式到另一种形式的分化。 这些 我的研究将成为我在杜克大学研究计划的一个组成部分 大学医学中心，并将导致正在进行的合作 我和奥珀多斯医生之间的关系

In recent years, much has been learned about the structural organization and regulation of the pathways of intermediary metabolism in the promastigote form of leishmania which lives in the intestinal tract of phlebotomine flies. Very little is known about the metabolism of the amastigote forms that live in the phagolysosome of human macrophages and cause leishmaniasis. It is now possible to grow the amastigote form of Leishmania mexicana pifanoi in axenic culture, and this opens the way to understanding its metabolism and to study the sequential changes that occur during differentiation from one form to the other. These studies will become an integral part of my research program at Duke University Medical Center and will lead to an ongoing collaboration between Dr. Opperdoes and myself.