DEVELOPING AND IMPROVING ANIMAL RESOURCES

拟议的动物资源改良项目的主要目标是 升级医疗中心科尔曼现有的中心动物设施 研究馆将为当前的环境提供最佳的控制 生物医学研究项目，并确保动物护理计划 符合美国农业部动物福利法、AAALAC关于 照顾实验动物，以及小灵通政策。这项改进计划 补充医疗中心升级Korman的总体计划 研究馆基础设施；它只要求资金用于改善 与中央动物设施直接相关。的具体目标 这项建议是为了： 1.改善和提升中心动物的环境管制 设施的供暖、通风和空调系统(HVAC)。这个 这些改进的结果将是能够控制 将动物区域控制在正负1或2度内，控制 相对湿度保持在40-60%，并保持适当的通风 费率。这将加强对老年人健康的保护 实验动物，并将限制环境变化， 影响研究人员的结果。 2.购置更多设备，如HEPA层流气流试验台和 带机架的附加微型隔离器单元。这台设备将是 整合到动物设施现有的微型隔离器系统中 提高有效的动物护理水平。 3.重铺目前已喷漆的地板，并须受 阻碍适当清洁的碎屑和表面不规则性。一个 与墙面相连的无缝、易于消毒的表面将 结果就是。 4.翻新现有的动物设施空间，提供可上锁的 与现有办公区相邻的行政支助室，即 通向其他房间的通道。然后，锁定区域将为 参考资料、CAF计算机和机密文件，如 协议。

The primary goal of the proposed animal resource improvement project is to upgrade the existing Central Animal Facility in the Medical Center's Korman Research Pavilion to provide optimal environmental controls for current biomedical research projects, and to ensure a program of animal care that is consistent with the USDA Animal Welfare Act, AAALAC recommendations for care of laboratory animals, and PHS policies. This plan for improvements supplements the Medical Center's overall plan for upgrading the Korman Research Pavilion infrastructure; it requests funding only for improvements directly relevant to the Central Animal Facility. The specific aims of this proposal are to: 1. Improve and upgrade the environmental controls of the Central Animal Facility's heating, ventilation, and air conditioning system (HVAC). The outcome of these improvements will be the ability to control temperature in the animal areas to within plus or minus 1 or 2 degrees, control the relative humidities at a rate of 40-60%, and maintain proper ventilation rates. This will provide increased protection for the health of the experimental animals and will limit environmental variations that can affect researchers' results. 2. Acquire additional equipment, such as a HEPA laminar air flow bench and additional microisolator units with racks. This equipment will be incorporated into the animal facility's existing microisolator system to improve effective animal care. 3. Resurface floors which are currently painted, and which are subject to chipping and surface irregularities that impede proper cleaning. A seamless, easily sanitized surface contiguous with wall surfaces will be the result. 4. Renovate existing animal facility space to provide a lockable administrative support room adjacent to the existing office area, which is a passageway to other rooms. The locked area will then provide storage for reference materials, the CAF computer, and confidential documents such as protocols.