FUNCTIONAL ORGANIZATION AND CONTROL OF HUMAN MASSETERS

我的长期职业目标包括：(1)保持 咀嚼领域富有成效和有意义的研究计划 运动控制；(2)对学生的教学产生积极影响 利用多学科方法(基础和临床科学)；以及 (3)提供最有效的评估和治疗服务 根据我们目前的知识，患者。在这两方面都有坚实的基础 在基础科学和临床领域，发展有意义的能力 假设并在科学基础上对其进行适当的检验可能是 增强版。因此，我的直接职业目标是完善和 扩展我在神经生理学领域的基本知识，以及更多 具体地说，在电机控制机制领域。RCDA会 提供一个机制：(1)发展基本背景；(2) 学习动物调查的实验室技术；(3)学习 哺乳动物肢体运动控制机制的直接参与 NIH正在资助三个实验室的研究以及一次休假 在大学之外；和)增加学科间的交流 基础和临床科学的思想，最终目标是 将这一更广泛的知识基础应用于调查 与健康相关的问题。整合了来自 佛罗里达大学(John Munson博士)和埃默里大学(A.W. 英格利希和T.R.Nichols博士)将在 神经再生后的运动控制领域，发育方面 以及姿势和僵硬的调节 以及它们与肌肉长度和力量变化、皮肤输入的关系 和脑干结构。此外，花六个月的假期 在另一个机构的RCDA时期接近尾声时，将进一步 拓宽我的背景。我会考虑有主修课程的实验室 研究的重点是咀嚼系统。这项研究将在 在非正式培训的同时，还将考察 控制的解剖学基础、功能组织和机制 人类咬肌(类似于A.W.英格利希博士的研究 在猫的后肢)。逻辑顺序之后将是第一个 检查咬肌内部解剖结构以确定其 结构分区，然后研究功能性神经肌肉 通过多点肌电记录对肌肉进行分区。经过一次彻底的 正常人咬肌功能组织的评价 没有疼痛的受试者，我们将检查无症状受试者 实验引起的面部疼痛。

Long term career objectives of mine consist of (1) maintaining a productive and meaningful research program in the area of masticatory motor control; (2) having a positive impact on the teaching of students by utilizing a multi-disciplinary approach (basic and clinical sciences); and (3) providing the most effective evaluation and treatment services to patients based on our current knowledge. With a firm foundation in both the basic sciences and clinical fields, the ability to develop meaningful hypotheses and test them appropriately on a scientific basis may be enhanced. My immediate career objective, therefore, is to refine and extend my basic knowledge in the field of neurophysiology, and more specifically, in the area of motor control mechanisms. The RCDA would provide a mechanism for: (1) developing the fundamental background; (2) learning laboratory techniques for animal investigations; (3) learning mammalian motor control mechanisms in the limb by direct participation in on-going NIH funded research in three laboratories as well as a sabbatical outside the University; and ) increasing the interdisciplinary exchange of ideas in the basic and clinical sciences with the ultimate objective of applying this broader base of knowledge towards investigating health-related problems. An integration of the expertise from the University of Florida (Dr. John Munson) and Emory University (Dr. A.W. English and Dr. T.R. Nichols) will provide a substantial experience in the area of motor control following nerve regeneration, developmental aspects of neuromuscular compartments, and the regulation of posture and stiffness and their relationship to muscle length and force changes, cutaneous inputs and brainstem structures. In addition, spending a six month sabbatical near the end of the RCDA period at another institution would further broaden my background. I would consider laboratories which have a major research focus on the masticatory system. The research to be conducted in parallel to the informal training will examine the basic fundamentals of the anatomical substrate, functional organization and mechanisms of control of the human masseter muscle (similar to the studies of Dr. A.W. English in cat hindlimb). A logical progression will be followed by first examining the masseter internal anatomical architecture to identify its structural partitions, and then study the functional neuromuscular compartments of the muscle by multi-site EMG recordings. After a thorough evaluation of the functional organization of the masseter muscle in normal subjects without pain, we will examine asymptomatic subjects with experimentally-induced facial pain.