Stronger together: understanding antibiotic synergy on a molecular level

该项目旨在使用基于基因组学的方法来回答有关抗生素协同作用如何发挥作用的基本问题。抗生素联合疗法为在其他耐药细菌中恢复抗生素的使用提供了机会，但目前对抗生素协同作用的分子机制知之甚少。研究表明，在协同杀灭过程中，除了原始抗生素的作用机制外，还会发生额外的作用机制(MOA)。该项目将识别参与多种协同治疗的基因，并确定细菌细胞如何获得抗药性。已确定的增效特异性MOA也代表了一个尚未开发的主要药物靶点的储藏库。

This project aims to use genomics-based approaches to answer fundamental questions about how antibiotic synergy works. Antibiotic combination therapy presents an opportunity to revive the use of antibiotics in otherwise resistant bacteria, yet currently there is little understanding of the molecular mechanisms underlying antibiotic synergy. Studies indicate that additional mechanisms of action (MOA) occur during synergistic killing beyond those of the original antibiotics. This project will identify genes involved in multiple synergistic treatments and determine how bacterial cells gain resistance. The synergy-specific MOA identified also represent an untapped reservoir of primary drug targets.