INTERACTIONS OF ANTIMITOTICS WITH TUBULIN ISOTYPES

我的近期目标是开始发展成为一名独立的研究人员， 拓宽我在药理学和生理学领域的知识基础。 为了实现这一目标，我建议调查 微管蛋白与抗有丝分裂剂的相互作用。 该项目将允许 我在生物化学和生物物理技术开发新的技能。 红豆杉生物碱和紫杉醇在临床上治疗 血液和实体肿瘤。 它们与微管蛋白结合，微管蛋白是一种主要的蛋白质， 细胞骨架，并在中期阻止细胞分裂;然而很少 是已知的原因变量的副作用发现与这些 毒品 由于微管蛋白同种型在不同组织中存在差异，我建议 研究同种型相互作用， 在组织水平上明显的效果。 提高我的技术技能， 评估基础科学研究问题的能力将提高我的 指导研究生进行研究和教学的能力 本科生和研究生生理学和药理学。 作为 长期目标，该项目将丰富的研究环境， 促进与护理学院的研究合作 药 现有的设备和教育机会， 对于这个项目来说，大学是绰绰有余的。 一部分 根据我的学习经验，我计划参加并参加基本的 科学研讨会和适当的课程。 我还计划参与 专业组织和发展与其他合作 科学家 这些活动将有助于发展护士之间的联系 和其他大学的基础科学家。 这个学术研究者奖将给我时间和资金 支持我以密集的方式进行研究，并将加快我的 作为一名独立的研究员。

My immediate goal is to begin to develop as an independent researcher and to broaden my knowledge base in the areas of pharmacology and physiology. In order to accomplish this goal I am proposing to investigate the interactions of tubulin with antimitotic agents. This project will allow me to develop new skills in biochemical and biophysical techniques. Vinca alkaloids and taxol are very important clinically in treating hematological and solid tumors. They bind to tubulin, a major protein of the cytoskeleton, and arrest cell division at metaphase; however little is known about the causes of the variable side effects found with these drugs. Since tubulin isotypes vary across tissues, I propose to investigate isotype interactions in an effort to shed light on side effects apparent at the tissue level. Improving my technical skills and ability to evaluate basic science research questions will enhance my ability to-guide graduate students in their research and to teach undergraduate and graduate students physiology and pharmacology. As a long term goal, this project will enrich the research environment of the School of Nursing and promote research collaboration with the School of Medicine. The available equipment and educational opportunities at this university are more than sufficient for this proposed project. As part of my learning experience, I plan to attend and participate in basic science seminars and appropriate courses. I also plan to be involved in professional organizations and develop collaborations with other scientists. These activities will help to develop links between nurses and basic scientists at this medical center and with other universities. This Academic Investigator Award would give me the time and financial support to pursue my research in an intensive manner and would hasten my development as an independent researcher.