NMR IMAGING IN DISEASES OF CEREBRAL WHITE MATTER

本研究计划的总体目标是开发和 验证质子磁共振（MR）成像技术， 可明确脑白色物质的神经病理基础 老年人的异常。 申请人拟确认 组织病理学和MR之间的特异性对应关系 临床病理学和MR之间的关系。 建议有两个组成部分：1）死后MR成像的 来自临床诊断为阿尔茨海默氏症的患者的大脑 疾病，由于梗死或 宾斯万格病，以及非痴呆患者， 脑血管疾病;和2）死前MR成像， 患有和不患有痴呆症的患者，以及 无脑血管疾病危险因素。 的关系 MR白色物质异常的存在和严重程度 临床综合征，如痴呆、动脉高血压， 不稳定的动脉压，如这些研究所制定的， 将指导申请人开发新型MR成像 技术，包括扩散和灌注成像。

The overall goal of this research proposal is to develop and validate proton magnetic resonance (MR) imaging techniques that can identify the neuropathologic bases of cerebral white matter abnormalities in the elderly. The applicant proposes to validate specific correspondences between histopathologic and MR phenomena and between clinical symptomatology and MR. The proposal has two components: 1) postmortem MR imaging of brains from patients with clinical diagnoses of Alzheimer's disease, patients with dementia due to infarction or to Binswanger's disease, and nondemented patients with and without cerebrovascular disease; and 2) antemortem MR imaging in patients with and without dementia, and in patients with and without risk factors for cerebrovascular disease. The relation of MR white matter abnormality to the presence and severity of clinical syndromes such as dementia, arterial hypertension, and labile arterial pressure, as formulated with these investigations, will guide the applicant in the development of novel MR imaging techniques, including diffusion and perfusion imaging.