NMR IMAGING IN DISEASES OF CEREBRAL WHITE MATTER

这项研究提案的总体目标是开发和 验证质子磁共振(MR)成像技术 可以确定脑白质的神经病理基础 老年人中的异常现象。申请者提议验证 组织病理学与MR的特异性对应关系 现象以及临床症状学和 建议有两个组成部分：1)尸检磁共振成像 临床诊断为阿尔茨海默病患者的大脑 疾病，因脑梗塞而患痴呆症的患者 Binswanger病和患有和不患有痴呆症的非痴呆患者 脑血管疾病；2)死前磁共振成像 患有和不患有痴呆症的患者，以及患有痴呆症和痴呆症的患者 无脑血管疾病危险因素。与中国的关系 MR脑白质异常对脑白质病变的存在和严重程度 临床症状，如痴呆症、动脉高血压和 根据这些研究得出的不稳定的动脉压， 将指导申请者开发新的磁共振成像 技术，包括扩散和灌注成像。

The overall goal of this research proposal is to develop and validate proton magnetic resonance (MR) imaging techniques that can identify the neuropathologic bases of cerebral white matter abnormalities in the elderly. The applicant proposes to validate specific correspondences between histopathologic and MR phenomena and between clinical symptomatology and MR. The proposal has two components: 1) postmortem MR imaging of brains from patients with clinical diagnoses of Alzheimer's disease, patients with dementia due to infarction or to Binswanger's disease, and nondemented patients with and without cerebrovascular disease; and 2) antemortem MR imaging in patients with and without dementia, and in patients with and without risk factors for cerebrovascular disease. The relation of MR white matter abnormality to the presence and severity of clinical syndromes such as dementia, arterial hypertension, and labile arterial pressure, as formulated with these investigations, will guide the applicant in the development of novel MR imaging techniques, including diffusion and perfusion imaging.