EGF EFFECTS ON RAT ORTHODONTIC TOOTH MOVEMENT AND MOLAR DRIFT

许多生物学效应都归因于EGF，包括 对长骨重塑的影响。表皮生长因子的主要来源是 大鼠是颌下腺。涎腺切除术(SX)已被证明 消耗唾液和血清中的EGF水平。这项研究是在 要确定EGF对牙槽骨的影响，可以通过以下几点来证明： 正畸牙齿移动(OTM)和磨牙移动(MD)。这个 经典的OTM曲线有三个部分，分别代表不同的 流程。初始运动代表组织变形。这个 延迟运动的第二阶段反映了细胞和 微环境的建立很好地允许 适当的组织和重塑。复会的最后阶段 运动代表组织的周转，它允许减少 施加的应变。大鼠的OTM也必须与自然的 磨牙向远中漂移的趋势约为7 微米/天。口服或不口服SX的疗效观察 应用EGF对雄性SD大鼠OTM和MD的影响 老鼠。成年大鼠(400-425g)分为以下几组 (n=5个/组)：1)Sx力(40克上颌初始倾斜力) 磨牙)；2)SX无力，EGF；4)假(Sh)，力；5Sh，力， 6)Sh，无力：7)Sh，无力，EGF。OTM和MD是 对于腭部植入物，确定使用口外 SX大鼠修复磨牙矫治时的脑电测量 漂移，改变了方向，提高了速度。同样，甚至 考虑到近侧漂移，接受EGF的SH动物表现出 明显刺激OTM的第二阶段，表现为两个- 牙齿移动量比单独在Sh中看到的增加一倍。它 似乎EGF可能参与了OTM的第二阶段和 正常上颌磨牙偏移。

Many biological effects have been attributed to EGF, including effects on long bone remodeling. The major source of EGF in the rat is the submandibular gland. Sialodenectomy (Sx) has been shown to deplete both salivary and serum EGF levels. This study was done to determine the effects of EGF on alveolar bone as evidenced by: orthodontic tooth movement (OTM) and molar drift (MD). The classical OTM curve has three parts that represents different processes. The initial movement represents tissue deformation. The second phase of delayed movement reflects recruitment of cells and the establishment of microenivronment that well allow the appropriate tissue and remodeling. The final phase of resumed movement represents tissue turnover which allows the reduction of the applied strain. OTM in rats must also contend with the natural tendency of molars to drift distally at the rate of ca. 7 micrometes m/day. The effects of Sx with or without orally administrated EGF on OTM and MD was studied in male Sprague-Dawley rats. Adult rats (400-425g) were divided into the following groups (n=5/group): 1)Sx, force (40 g initial tipping force to maxillary molars); 2) SX no force, EGF; 4) Sham (Sh), force; 5 Sh, force, EGF; 6) Sh, no force: 7) Sh, no force, EGF. OTM and MD were determined, with respect to palatal implants, using extraoral cehpalometrics obtained at appliance to Sx rats restored molar drift, changed its direction and enhanced its rate. Similarly, even accounting for mesial drift, SH animals receiving EGF showed a marked stimulation of the second phase of OTM, exhibiting a two- fold increase in tooth movement over that seen in Sh alone. It appears that EGF may be involved in the second phase of OTM and in normal maxillary molar drift.