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LYMPHATIC METASTASIS OF MELANOMA TUMOR CELLS

LYMPHATIC METASTASIS OF MELANOMA TUMOR CELLS
黑色素瘤细胞的淋巴转移
批准号:
3088581
负责人:
DANIEL M RAMOS
金额:
$7.12万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-07-01 至 1993-06-30

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中文摘要
翻译
肿瘤细胞与细胞外基质的相互作用 将对发现的淋巴结内进行研究。了解如何 肿瘤细胞侵入淋巴管并与 细胞外基质的成分可以解释为什么会这样 组织是肿瘤细胞生长的肥沃环境。这是 尤其与头颈部癌有关,其中淋巴转移 转移是肿瘤扩散的主要机制。这个 具体目的是(1)确定小鼠B16黑色素瘤的特征 淋巴转移模型;(2)检测粘附性。 转移细胞到淋巴组织元素;(3)检查 肿瘤细胞表面黏附受体在细胞外的作用 矩阵交互作用。
英文摘要
The interactions of tumor cells with the extracellular matrix found within the lymph nodes will be studied. Understanding how tumor cells invade the lymphatics and interact with the components of the extracellular matrix may explain why this tissue is such a fertile environment for tumor cell growth. This is especially relevant to head and neck cancers in which lymphatic metastasis is the primary mechanism of tumor dissemination. The specific aims are (1) to characterize the mouse B16 melanoma model for lymphatic metastasis; (2) to examine the adhesion of metastatic cells to lymph node tissue elements; (3) to examine the role of tumor cell surface adhesion receptors in extracellular matrix interactions.
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