MINORITY SCHOOL FACULTY DEVELOPMENT AWARD

本研究的主要目标是评估过度紧张的作用。 紧张对动脉粥样硬化发展的两种不同影响 动脉床，颈动脉和主动脉，并确定 这两张床的反应相同或不同 使用钙阻滞剂硝苯地平进行干预。这个 需要检验的假设是颈动脉粥样硬化 高血压动物的发展速度要快得多， 与主动脉粥样硬化相比，动脉粥样硬化更不容易退化。 白色卡诺鸽子，6-12个月龄，雌雄不限，来自 遗传选择的高(n=91)和低(n=91)血压 将对线路进行研究。每一列中的鸟将被分成 四组，分别喂以致动脉粥样硬化的饮食或对照饮食。 两组鸽子也将被喂食硝苯地平和 致动脉粥样硬化饮食。血压，体重，血浆胆固醇， 血钙和血浆脂蛋白浓度将 最初测量，在研究期间的3个月和10个月时测量。之后 10个月后，将对鸽子分组进行检查，以评估 动脉硬化。剩下的鸽子将被从 并将其分为三个亚组。在任何时候 动脉粥样硬化消退期，对照饮食加或不加 硝苯地平将再服用10个月。鸟儿们会 通过肉眼检查来评估动脉粥样硬化， 动脉总胆固醇、钙、胶原和弹性蛋白 浓度。组织切片将被检查以支持 生化研究。这个项目的意义在于 更好地了解高血压在高血压中的作用 动脉粥样硬化在动脉和颈动脉中的发展及意义 这两种动脉床对饮食干预的反应和 钙通道阻滞剂硝苯地平的作用。

The major goal of the present study is to assess the role of hyper- tension on the development of atherosclerosis in two different arterial beds, the carotid artery and aorta, and to determine similarities or differences in the responses of these two beds to intervention with the calcium blocking agent, nifedipine. The hypothesis to be tested is that carotid artery atherosclerosis in hypertensive animals develops at a significantly greater rate and is less subject to regression compared to aortic atherosclerosis. White Carneau pigeons, aged 6-12 months and of either sex, from genetically selected high (n=91) and low (n=91) blood pressure lines will be studied. The birds in each line will be divided into four groups and will be fed either an atherogenic or control diet. Two groups of pigeons will also be fed nifedipine along with the atherogenic diet. Blood pressure, body weight, plasma cholesterol, blood calcium and plasma lipoprotein concentrations will be measured initially, and at 3 and 10 months during the study. After 10 months, subgroups of pigeons will be examined to assess atherosclerosis. The remaining pigeons will be removed from the atherogenic diet and divided into three subgroups. During any atherosclerosis regression phase, a control diet with or without nifedipine will be fed for an additional 10 months. The birds will be sacrificed and atherosclerosis evaluated by visual examination, total arterial cholesterol, calcium, collagen and elastin concentrations. Histologic sections will be examined to support the biochemical studies. The significance of the project lies in a better understanding of the role of hypertension in atherosclerosis development in aorta and carotid artery and the response of these two arterial beds to dietary intervention and the effect of the calcium channel blocker, nifedipine.