SPECIALIZED CENTER OF RESEARCH IN ARTERIOSCLEROSIS

该SCOR计划的目标是在七个项目中阐明， 血浆脂蛋白与动脉粥样硬化关系 等离子体结构和功能的广泛研究 脂蛋白在正常条件下和与 加速动脉粥样硬化形成。 1)载脂蛋白的结构和功能：本项目将 研究的物理结构和功能域 载脂蛋白B，确定几个新认识的结构 载脂蛋白，以及从载脂蛋白中洗脱的脂蛋白的结构。 动脉粥样硬化斑块 2)催化蛋白的结构与功能关系 胆固醇转运途径：本项目将利用定点 突变来阐明这些关键基因中的重要功能区域， 胆固醇逆向转运蛋白，胆固醇是通过这种蛋白转运的。 从动脉粥样硬化斑块中移除。 3)新生血浆脂蛋白在肝细胞中的组装 将阐明组装潜在致动脉粥样硬化和 抗动脉粥样硬化脂蛋白。 4)肝脏在脂蛋白催化剂中的作用：本项目将 阐明机制，其中动脉粥样硬化脂蛋白被删除， 血液和这些过程的调节。 项目3和4可能 导致新的方法来调节致动脉粥样硬化的浓度， 抗动脉粥样硬化的脂蛋白。 5)逆转胆固醇转运和动脉壁：该项目 将决定高密度脂蛋白的种类如何吸收， 将细胞和血浆胆固醇分解并传递给其他脂蛋白 通过肝脏清除，并将促进我们对 胆固醇从动脉壁中清除的机制。 6)遗传性异常脂蛋白血症：基因组决定因素和功能 结果：该项目，通过阐明家族性的基因组机制， 异常脂蛋白血症及其对脂蛋白的影响 相互转换和catalysts，将增加我们对 致动脉粥样硬化性血脂异常的基础。 7)冠状动脉疾病的餐后脂质代谢：该项目 将研究血浆甘油三酯和胆固醇的异常 在餐后状态的运输，以提供新的见解， 动脉粥样硬化和抗动脉粥样硬化药物代谢的动态变化 脂肪摄入后的脂蛋白。 SCOR将由三个 核心单位：脂质诊所，实验室和行政单位。 整个计划将形成一个有凝聚力和连贯性的攻击中央 血浆脂蛋白与动脉粥样硬化形成的关系。

The objective of this SCOR program is to elucidate, in seven projects, the relationship between plasma lipoproteins and atherosclerosis by a broad range of investigations of the structure and function of the plasma lipoproteins under normal conditions and in states associated with accelerated atherogenesis. 1) Structure and function of apolipoproteins: This Project will investigate the physical structure and functional domains of apolipoprotein B, determine the structure of several newly recognized apolipoproteins, and the structure of lipoproteins eluted from atherosclerotic plaques. 2) Structure-function relationships of catalytic proteins in the reverse cholesterol transport pathway: This Project will utilize site-directed mutagenesis to elucidate functionally important regions in these key proteins of reverse cholesterol transport, by which cholesterol is removed from atherosclerotic plaques. 3) Assembly of nascent plasma lipoproteins by hepatocytes: This Project will elucidate the steps in the assembly of potentially atherogenic and antiatherogenic lipoproteins in the liver. 4) Role of the liver in lipoprotein catabolism: This Project will elucidate mechanisms by which atherogenic lipoproteins are removed from the blood and the regulation of these processes. Projects 3 and 4 may lead to new approaches to regulate the concentration of atherogenic and antiatherogenic lipoproteins in the blood. 5) Reverse cholesterol transport and the arterial wall: This Project will determine how species of high density lipoproteins take up and esterify cell and plasma cholesterol and deliver it to other lipoproteins for removal by the liver, and will advance our understanding of the mechanisms by which cholesterol is removed from arterial walls. 6) Genetic dyslipoproteinemia: genomic determinants and functional consequences: This project, by elucidating genomic mechanisms of familial dyslipoproteinemias and the effects of these disorders upon lipoprotein interconversions and catabolism, will increase our understanding of the basis of atherogenic dyslipoproteinemias. 7) Postprandial lipid metabolism in coronary artery disease: This project will investigate abnormalities of plasma triglyceride and cholesterol transport in the postprandial state to provide new insights into the dynamic changes in metabolism of atherogenic and antiatherogenic lipoproteins after fat ingestion. The SCOR will be supported by three Core Units: a Lipid Clinic, Laboratories, and an Administrative Unit. The entire program will form a cohesive and coherent attack upon central issues of the relationship between plasma lipoproteins and atherogenesis.