DUKE-VA CENTER FOR CEREBROVASCULAR RESEARCH

本提案的目的是开展一项全面的研究， 该计划的重点是研究脑血管疾病及其 后遗症 这些项目包括相关的临床和放射学 中风风险患者的研究， 抗血小板药物，缺血性脑毛细血管增生的研究， 多巴胺受体的研究，以及从多巴胺受体释放的儿茶酚胺的研究。 肾上腺髓质细胞 有几个研究神经元 海马的可塑性，去甲肾上腺素能神经元之一， 肾上腺素能和胆碱能受体，一个相关的恢复空间 中隔损伤后的行为，一个研究海人酸后遗症 注射和一个研究enhaphalins和其他 神经递质在脑损伤后癫痫发作中的作用 一 最后一组项目集中在感觉皮层的神经功能 初级传入通路损伤后，细胞间相互作用，以及 对培养神经元的膜生物化学的影响。 这些项目反映了 许多实验方法来理解中风，并继续 强调理解功能恢复的生物学基础， 中风

The objective of this proposal is to carry out a comprehensive research program focussed on the study of the cerebrovascular disease and its sequelae. The projects inlcude a correlative clinical and radiological study of patients at risk for stroke, a pharmacokinetic study of antiplatelet drugs, a study of capillary proliferation in ischemic brain, a study of dopamine receptors, and a study of catecholamine release from adrenal medullary cells. There are several projects studying neuronal plasticity in the hippocampus, one of noradrenergic neurons, one of adrenergic and cholinergic receptors, one correlating recovery of spatial behavior after septal lesions, one studying the sequelae of kainic acid injection and one studying the role of enhaphalins and other neurotransmitters in the development of seizures after brain injury. A final group of projects focusses on neuronal function of the senory cortex after injury to primary afferent pathways, on cell-cell interactions, and on the membrane biochemistry of cultured neurons. The projects reflect a number of experimental approaches to understanding stroke and continues to emphasize understanding the biological basis of recovery of function after stroke.