A PROSPECTIVE LONG TERM FOLLOW-UP OF ALCOHOLICS

这项被提议的项目是对259名酗酒者的纵向跟踪研究 (156男子和103名妇女）连续承认两个圣路易斯 1967-68年的精神病医院，并根据 一级或二级酗酒者。 NIMH诊断访谈时间表将用于确定当前 以及终生精神疾病的发病率。 本研究的目的是：1）描述 酗酒; 2）检查结果变化的具体预测因素 （包括发病率、死亡率和饮酒状况） 选定的社会和精神变量，包括诊断亚型 酒精中毒，性别，种族，家族精神病史，早期与晚期 酒精中毒的发病情况和社会经济状况; 3）确定是否 成功的长期调整模式在基因定义的 酗酒者的亚型;和4）探索之间的关联 酒精中毒的诊断亚型和长期结果，并观察 酗酒诊断亚组在22年内的稳定性。 这些信息将有助于告知研究人员的最佳点， 检查结果研究的随访时间。它将进一步帮助 临床医生设计和实施所需的治疗服务。

The proposed project is a longitudinal follow-up study of 259 alcoholics (156 men and 103 women) consecutively admitted to two St. Louis psychiatric hospitals in 1967-68 and classified at index according to explicit criteria as primary or secondary alcoholics. The NIMH Diagnostic Interview Schedule will be used to ascertain current as well as lifetime psychiatric disorders in this population. Goals of the study are 1) to describe the long term course and outcome of alcoholism; 2) to examine specific predictors of variation in outcome (including morbidity and mortality and drinking status) according to selected social and psychiatric variables, including diagnostic subtypes of alcoholism, sex, race, family psychiatric history, early vs. late onset of alcoholism, and socio-economic status; 3) to determine whether patterns of successful long-term adjustment vary in genetically defined subtypes of alcoholics; and 4) to explore the association between diagnostic subtypes of alcoholism and long-term outcome and observe the stability of the diagnostic subroups of alcoholism over a 22-year period. This information will help inform researchers of the optimal point in time for follow-up in examination of outcome studies. It will further aid clinicians in designing and implementing needed treatment services.