NEUROENDOCRINOLOGY OF ALCOHOLISM

慢性酒精中毒有时与假性库欣有关 综合征和正常甲状腺病态综合征。有一些具体的 HPA和HPT轴功能异常 综合症。然而，目前还不清楚这些功能是否 异常(1)是由实际虐待引起的或与实际虐待有关 酒精或(2)甚至存在于酗酒者体内 在戒酒期间，因此可能代表 下丘脑某些潜在功能障碍的表现 或者是酗酒者的下丘脑输入。(3)倾向于 在相同的个体中共存，以及(4)倾向于与 特定的认知行为表现。我们假设 相当大比例的戒酒者，比如病人 患有原发性抑郁症的患者，对CRH和 TRH，正如初步研究结果所示 我们和其他调查人员。我们进一步假设 钝化是由于主音和/或搏动的慢性增加。 CRH和TRH的释放继发于活性改变 这些释放荷尔蒙的脉冲发生器(S)，就像已经做的那样 建议用于原发性抑郁症的HPA轴。我们建议 研究基础的、非刺激的每日释放模式 促肾上腺皮质激素和促甲状腺激素--以及它们目标腺体的激素产物-- -以及他们对静脉注射的反应。人工合成的CRH和 戒酒六周的慢性酒精中毒者的TRH。 我们将使用计算机辅助的脉搏分析程序来检查 昼夜节律研究数据。这项计划有一个增强的 能够排除假阳性脉冲，从而产生更多 对较少数量的每日脉动事件的准确定义 比之前认为的存在的要多。对CRH的反应 TRH将在幅度和时序的基础上进行分析 峰值激素浓度和总积分 释放出大量的荷尔蒙。因为缺乏合适的 控制数据，我们将检查昼夜节律和响应 CRH和TRH在年龄、种族和社会经济匹配中的关系 不酗酒的志愿者。最后，酗酒患者的 将研究认知行为特征，以确定是否有 临床精神病学与神经内分泌学相关吗？ 功能障碍。

Chronic alcoholism is sometimes associated with pseudo-Cushing's syndrome and euthyroid sick syndrome. There are specific abnormalities in HPA and HPT axis function that characterize these syndromes. It is as yet unclear, however, whether these functional abnormalities (1) are caused by or associated with the actual abuse of alcohol or (2) are present in the alcoholic individual even during abstinence from alcohol and may, therefore, represent manifestations of some underlying dysfunction of the hypothalamus or of hypothalamic inputs in alcoholic individuals. (3) tend to coexist in the same individuals, and (4) tend to be associated with specific cognitive behavioral manifestations. We hypothesize that a significant percentage of abstinent alcoholics, like patients with primary depression, will have blunted responses to CRH and TRH, as has been indicated by the results of preliminary studies by us and by other investigators. We further postulate that the blunting is due to a chronic increase in the tonic and/or pulsatile release of CRH and TRH secondary to an alteration in the activity of the pulse generator(s) for these releasing hormones, as has been suggested for the HPA axis in primary depression. We propose to study both the basal, unstimulated diurnal pattern of release of ACTH and TSH -- and the hormonal products of their target glands - - and their responses to i.v. administration of synthetic CRH and TRH in chronic alcoholic men who have been abstinent for six weeks. We will use a computer-assisted pulse analysis program to examine the diurnal rhythm study data. This program has an enhanced ability to exclude false-positive pulses, resulting in more accurate definition of a smaller number of daily pulsatile events than had previously been assumed to exist. The responses to CRH and TRH will be analyzed on the basis of the amplitude and timing of the peak hormone concentrations and the total integrated quantities of hormones released. Because of the lack of suitable control data, we will examine both the diurnal rhythm and responses to CRH and TRH in age-, race-, and socioeconomic-matched nonalcoholic volunteer men. Finally, the alcoholic patients' cognitive behavioral profiles will be studied to determine if there are clinical psychiatric correlates of the neuroendocrinologic dysfunction.