IV ANESTHETIC DISPOSITION IN THE AGED HEMODYNAMIC STATE

提出了一系列的理论研究，以发展和 评估解决备选方案的统计方法 关于遗传和环境决定因素的假设 老龄化和与年龄相关的疾病。关于遗传的四种方法 将调查与年龄相关的现象的分析：扩展 结合遗传和环境的时间序列模型 影响；分析相互关联的程度和原因 疾病易感性和发病年龄；统计-遗传学 与年龄相关的体内平衡控制退行性变化的后果 基因调控和对环境的敏感性 将遗传和环境异质性纳入到 生存分析模型或年龄相关事件。电脑 将开发程序来模拟和分析亲属关系数据 在每个主要感兴趣的领域，主要目标是 决定与年龄相关的定量遗传学研究的程度 现象可以解释遗传和环境过程。 在衰老过程的不同方面。解决方案 将探索不同策略的力量，以及 评估推理的偏差和错误。适当的方法将 应用于来自大型纵向研究的说明性数据 双胞胎及其父母(N=330个家庭)和 对常见年龄相关性疾病及其相关疾病的研究 两项关于双胞胎及其亲属的大型研究中的危险因素 (N=5,000对，N=14000对双胞胎外加7,000名亲属， 大约)。到五年计划结束时， 可用于遗传研究的理论和计算工具 进入老龄化阶段应得到显著加强。

A series of theoretical studies are proposed to develop and evaluate statistical approaches to resolving alternative hypotheses about the genetic and environmental determinants of aging and age-related diseases. Four approaches to the genetic analysis of age-related phenomena will be investigated: extension of time series models to incorporate genetic and environmental effects; analysis of the extent and cause of correlation between disease liability and age of onset; the statistical-genetic consequences of age-related degeneration of homeostatic control of gene regulation and sensitivity to the environment the incorporation of genetic and environmental heterogeneity into survival analysis models or age-dependent events. Computer programs will be developed to stimulate and analyze kinship data in each of the major areas of interest with the principal goal of deciding how far quantitative genetic studies of age related phenomena can elucidate the genetic and environmental processes underlying different aspects of the aging process. The resolving power of different strategies will be explored, and the effects of bias and errors of inference assessed. Appropriate methods will be applied to illustrative data from a large longitudinal study of cardiovascular risk in twins and their parents (N=330 families) and to a study of common age-dependent disease and disease-related risk factors in two large studies of twins and their relatives (N=5000 pairs and N=14000 twins plus 7000 relatives, approximately). By the end of the five year project the theoretical and computational tools available to genetic research into aging should be significantly enhanced.