A PROSPECTIVE LONG TERM FOLLOW-UP OF ALCOHOLICS

拟议的项目是对259名酗酒者的纵向跟踪研究。 (156名男性和103名女性)连续两次进入圣路易斯 1967-68年度的精神病院数目，并按下列指数分类 明确的标准为一级或二级酗酒者。 将使用NIMH诊断性面谈时间表来确定当前 以及这一人群的终生精神障碍。 这项研究的目标是1)描述长期的过程和结果 酒精中毒；2)检查结果变化的特定预测因素 (包括发病率、死亡率和饮酒情况) 选定的社会和精神变量，包括诊断亚型 酗酒、性别、种族、家族精神病史，早期与晚期 酒精中毒的发病情况和社会经济地位；3)确定 成功的长期调整模式在基因定义上各不相同 酗酒者的亚型；以及4)探索两者之间的联系 酒精中毒的诊断亚型及远期结局观察 酒精中毒诊断亚群在22年期间的稳定性。 这些信息将帮助研究人员了解 检查结果研究的后续行动的时间。它将进一步帮助 临床医生设计和实施所需的治疗服务。

The proposed project is a longitudinal follow-up study of 259 alcoholics (156 men and 103 women) consecutively admitted to two St. Louis psychiatric hospitals in 1967-68 and classified at index according to explicit criteria as primary or secondary alcoholics. The NIMH Diagnostic Interview Schedule will be used to ascertain current as well as lifetime psychiatric disorders in this population. Goals of the study are 1) to describe the long term course and outcome of alcoholism; 2) to examine specific predictors of variation in outcome (including morbidity and mortality and drinking status) according to selected social and psychiatric variables, including diagnostic subtypes of alcoholism, sex, race, family psychiatric history, early vs. late onset of alcoholism, and socio-economic status; 3) to determine whether patterns of successful long-term adjustment vary in genetically defined subtypes of alcoholics; and 4) to explore the association between diagnostic subtypes of alcoholism and long-term outcome and observe the stability of the diagnostic subroups of alcoholism over a 22-year period. This information will help inform researchers of the optimal point in time for follow-up in examination of outcome studies. It will further aid clinicians in designing and implementing needed treatment services.