SENSORY BASIS FOR BEHAVIOR IN MOSQUITOES

传染病和寄生虫病占总死亡率的40% 在发展中国家，其中很大一部分是疾病 比如黄热病、疟疾、丝虫病、登革热和脑炎--所有这些 由蚊子携带。媒介传播引起的疾病和衰弱 疾病给全球经济造成了毁灭性的损失。这种情况 用于控制天牛的杀虫剂成本不断攀升，加剧了这一问题 显示出不断增加的耐化学性的媒介。更多 迫切需要有效的控制策略；这些可能是最重要的 合理而有效地设计，如果人的生理和行为 向量被考虑在内。 目前的申请是为了继续一个项目，该项目具有 它的总体目标是阐明控制 气味在蚊子中的行为。这些行为包括 寻找寄主、产卵和植物取食是至关重要的 在蚊子繁殖和流行病学能力方面。寻找主机的IS 雌虫对寄主挥发物和寄主的远距离定向 在性腺营养周期中受作用于 外周感觉系统以这样的方式呈现雌性 功能上以乳酸为引诱剂，以宿主为引诱剂。我们已经做出了 内源性因子的分离和鉴定研究进展 埃及伊蚊的远程宿主吸引力，我们已经将我们的 观察寄主寻找等行为进入神经生理学 解释差异行为的行为控制模型 在这个物种中的表达。我们在此应用程序中的具体目标是 在其他种类的蚊子中测试我们模型的预测，并 继续我们在提纯和表征方面的工作 寻找寄主的内源抑制物。

Infectious and parasitic diseases' account for 40% of the total mortality in developing countries, and a significant proportion of these are diseases such as yellow fever, malaria, filariasis, dengue, and encephalitis--all carried by mosquitoes. The morbidity and debility caused by vector-borne diseases exert a devastating toll on the global economy. This situation is exacerbated by the escalating cost of insecticides for the control of vectors that display ever-increasing levels of chemical resistance. More effective control strategies are urgently needed; these can be most rationally and effectively designed if the physiology and behavior of the vector are taken into consideration. The current application is for the continuation of a project that has as its overall goal the elucidation of the mechanisms that control odor-mediated behaviors in the mosquito. Such behaviors include host-seeking, oviposition, and plant feeding and are of critical importance in mosquito reproduction and epidemiological competence. Host-seeking is the long-distance orientation of the female to host volatiles and is modulated during the gonotrophic cycle by endogenous factors that act on the peripheral sensory system in such a way as to render the female functionally anosmic to the host attractant lactic acid. We have made progress in isolating and identifying the endogenous factors that prevent long-range host attraction in Aedes aegypti, and we have incorporated our observations of host-seeking and other behaviors into a neurophysiological model of behavioral control that explains differential behavioral expression in this species. Our specific aims in this application are to test the predictions of our model in other species of mosquitoes and to continue our work on the purification and characterization of the endogenous inhibitors of host-seeking.